Inhibitory effects on nuclear factor κB of the Vietnamese freshwater cyanobacteria

Several Vietnamese freshwater cyanobacteria were collected and evaluated for their effects on the transcriptional nuclear factor κB (NF-κB) which are involving in the cancer and inflammatory diseases. Five extraction conditions were tested and a solution of 2% acetic acid in methanol provided highes...

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Published inMedicinal chemistry research Vol. 20; no. 6; pp. 790 - 793
Main Authors Nguyen, Tien Dat, Duong, Thi Thuy, Le, Thi Phuong Quynh, Chau, Van Minh, Le, Minh Ha, Dang, Dinh Kim, Lee, Jung Joon, Bourguet-Kondracki, Marie-Lise
Format Journal Article
LanguageEnglish
Published New York Springer-Verlag 01.07.2011
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
NF-κB
Cytotoxicity
sp
Cyanobacteria
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Summary:Several Vietnamese freshwater cyanobacteria were collected and evaluated for their effects on the transcriptional nuclear factor κB (NF-κB) which are involving in the cancer and inflammatory diseases. Five extraction conditions were tested and a solution of 2% acetic acid in methanol provided highest yield of extract from bacterial biomass. The Microcystis aeruginosa TC-1 and TC-3 strains showed strong NF-κB inhibitory activity with IC 50 values of 6.1 and 5.3 μg/ml, respectively. Moreover, all tested cyanobacteria exhibited cytotoxicity on human cervical cancer HeLa cells in a dose-dependent manner. Ergosterol (1) isolated from M. aeruginosa TC-3 strains strongly inhibited NF-κB activation with IC 50 values of 0.91 μg/ml.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-010-9409-z