Modern catalysis in the synthesis of some pharmaceuticals and fine chemicals

• Published in: Hemijska industrija Vol. 56; no. 1; pp. 10 - 16
• Main Authors: Petrovic, Slobodan, Misic-Vukovic, Milica, Mijin, Dusan
• Format: Journal Article
• Language: English
• Published: Belgrade Hemijska Industrija 2002; Association of Chemical Engineers of Serbia
• Subjects: asymmetric catalysis; biocatalysis; Catalysis; catalysts; Chemical industry; Chemical synthesis; Fine chemicals; Pharmaceuticals; phase-transfer catalysis; solid phase catalysis; synthesis
• ISSN: 0367-598X; 2217-7426
• DOI: 10.2298/HEMIND0201010P

Catalysis in the synthesis of Pharmaceuticals and line chemicals nowadays becomes more and more important. Synthesis that minimizes wastes is important from the economical aspect, as well as from the environmental aspect. "Green chemistry" or "green technology" is an effort to protect the environment by increasing the efficiency of the overall synthetic processes in the chemical industry by minimizing or eliminating wasteful by-products. Modern catalytic methods in the synthesis of some Pharmaceuticals and fine chemicals are discussed such as phase-transfer catalysis, biocatalysis asymmetric catalysis and, generally, solid-phase chemistry. Kataliza u sintezi farmaceutskih sirovina i finih hemikalija sve vise poprima na znacaju. Sinteza koja smanjuje kolicinu otpadnih materija znacajna je kako sa ekonomskog tako i sa ekoloskog znacaja. "Zelena hemija", ili "zelena tehnologija" predstavljaju pokusaj da se zastita covekove okoline dovede na visi nivo povecanjem efikasnosti pri izvodjenju sintetskih procesa u hemijskoj industriji, smanjenjem ili eliminisanjem sporednih proizvoda. U okviru ovoga rada dat je pregled savremenih katalitickih metoda u sintezi nekih farmaceutskih sirovina i finih hemikalija. U tom cilju dat je pregled sinteza koje ukljucuju primenu medjufazne katalize, biokatalize asimetricne sinteze, i generalno sinteze na cvrstoj fazi.