Effect of indigestible dextrin on cholesterol metabolism in rat

• Published in: Nihon Eiyō, Shokuryō Gakkai shi Vol. 44; no. 6; pp. 471 - 478
• Main Authors: Wakabayashi, S. (Matsutani Chemical Industry Co. Ltd., Itami, Hyogo (Japan)), Satouchi, M, Nogami, Y, Ohkuma, K, Matsuoka, A
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Nutrition and Food Science 1991
• Subjects: CHOLESTEROL; COLESTEROL; DEXTRINAS; DEXTRINE; DEXTRINS; dietary fiber; indigestible dextrin; lipid metabolism; lowering cholesterol; METABOLISM; METABOLISME; METABOLISMO; RAT; RATA; RATS; short chain fatty acid
• ISSN: 0287-3516; 1883-2849
• DOI: 10.4327/jsnfs.44.471

Using an indigestible dextrin (PF: 58.2% dietary fiber and PF-C: 91.6% dietary fiber as determined by HPLC) obtained through pyrolysis of potato starch, its effects on cholesterol metabolism in rats were evaluated. The results are summarized as follows: 1) The levels of serum cholesterol and trigIyceride ia rats fed a cholester01-free diet for 5 weeks were significantly decreased from 119±7.6mg/dl and 218±39.0mg/dl to 94.2±6.0mg/dl and 145±20.0mg/dl, respectively, following supplementation of 10% PF-C; 2) When rats on a standard diet were supplied with tap-water admixed with 20% PF and 5-20% PF-C against a control for 5 weeks, serum and liver cholesterol levels were significantly decreased according to the magnitude of the change in dietary fiber content; 3) Total bile acid excretion in feces was significanly increased in both the PF and PF-C groups; 4) The content of total short-chain fatty acids, especially propionic acid, in fecal volume rose significantly in both the PF and PF-C groups; 5) Confirmation of the effect of PF-C on serum and liver cholesterol levels was made by switching the drinking water from ordinary tap-water to the PF-C solution.