MCM structure and mechanics: what we have learned from archaeal MCM

Minichromosome maintenance (MCM) complexes have been identified as the primary replicative helicases responsible for unwinding DNA for genome replication. The focus of this chapter is to discuss the current structural and functional understanding of MCMs and their role at origins of replication, whi...

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Bibliographic Details
Published inSub-cellular biochemistry Vol. 62; p. 89
Main Authors Slaymaker, Ian M, Chen, Xiaojiang S
Format Journal Article
LanguageEnglish
Published United States 2012
Subjects
Archaea - physiology
Archaeal Proteins - genetics
Archaeal Proteins - metabolism
DNA Replication - physiology
DNA, Archaeal - biosynthesis
DNA, Archaeal - genetics
Genome, Archaeal - physiology
Minichromosome Maintenance Proteins - genetics
Minichromosome Maintenance Proteins - metabolism
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Summary:Minichromosome maintenance (MCM) complexes have been identified as the primary replicative helicases responsible for unwinding DNA for genome replication. The focus of this chapter is to discuss the current structural and functional understanding of MCMs and their role at origins of replication, which are based mostly on the studies of MCM proteins and MCM complexes from archaeal genomes.
ISSN:0306-0225
DOI:10.1007/978-94-007-4572-8_6