Animal models in cardiovascular diseases: new insights from conditional models

Conditional systems have proven to be efficient and powerful to delineate several aspects of cardiac pathophysiology and diseases. The possibility of addressing a particular time point in animal life is certainly an important breakthrough allowed by conditional strategies with temporal control of ei...

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Bibliographic Details
Published inHandbook of experimental pharmacology no. 178; p. 377
Main Authors Nguyen Din Cat, A, Sainte-Marie, Y, Jaisser, F
Format Journal Article
LanguageEnglish
Published Germany 2007
Subjects
Animals
Cardiovascular Diseases - pathology
Disease Models, Animal
Homeostasis
Recombinases - metabolism
Tetracycline - pharmacology
Trans-Activators - metabolism
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Summary:Conditional systems have proven to be efficient and powerful to delineate several aspects of cardiac pathophysiology and diseases. The possibility of addressing a particular time point in animal life is certainly an important breakthrough allowed by conditional strategies with temporal control of either transgene expression or gene modifications. The purpose of this review is to present various mouse models for cardiovascular diseases based on conditional approaches.
ISSN:0171-2004
DOI:10.1007/978-3-540-35109-2_16