A translation of technology: Microcoat to sustained release orally disintegrating tablets

Orally disintegrating tablets (ODTs) comprising sustained release (SR) coated microparticles smaller than 250 mum provide an appealing dosage form for patients with dysphagia, offering a superior mouthfeel and highly convenient route of administration without the need for water. SR coating for micro...

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Bibliographic Details
Published inBritish Journal of Pharmacy Vol. 7; no. 2; pp. S1 - S2
Main Authors Patel, Kavil, Murnane, Darragh, Richardson, Craig, Liu, Fang
Format Journal Article
LanguageEnglish
Published Huddersfield, United Kingdom University of Huddersfield Press 01.11.2022
Subjects
coating
Coatings
Controlled release
Deglutition disorders
Drugs
dysphagia
Evaluation
Excipients
microparticles
sustained release
sustained release; microparticles
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Summary:Orally disintegrating tablets (ODTs) comprising sustained release (SR) coated microparticles smaller than 250 mum provide an appealing dosage form for patients with dysphagia, offering a superior mouthfeel and highly convenient route of administration without the need for water. SR coating for microparticles of the requisite size (<200 mum) is incredibly challenging however the utilisation of the MicroCoat technology, whereby various dry powder glidants are added during SR coating, was demonstrated to achieve desirable coating outcomes. ODTs were prepared via direct compression. In addition to conventional USP methods, texture analysis (TA) was applied to determine disintegration. ODTs were shown to disintegrate within an acceptable time (<30s) and drug release was unaffected by compression during tabletting indicating a robust coating.
Bibliography:British Journal of Pharmacy, Vol. 7, No. 2, Nov 2022, S1-S2
Informit, Melbourne (Vic)
ISSN:2058-8356
2058-8356
DOI:10.5920/bjpharm.1142