Evaluation of Khaya gum ('Khaya senegalensis') as a polymer in the formulation of floating in situ gels of metoprolol succinate

• Published in: British Journal of Pharmacy Vol. 8; no. 1; pp. 1 - 9
• Main Authors: Okunlola, Adenike, Durodola, Iyanu Abisoye
• Format: Journal Article
• Language: English
• Published: Huddersfield, United Kingdom University of Huddersfield Press 01.04.2023
• Subjects: Biopolymers; Drug delivery systems; Evaluation; floating drug delivery system; in situ gel; Khaya; khaya gum; Methodology; Metoprolol; metoprolol succinate; sustained release
• ISSN: 2058-8356; 2058-8356
• DOI: 10.5920/bjpharm.1011

Metoprolol succinate, a beta-selective adrenergic blocker, has a short half-life, low bioavailability, and high dosing frequency. 'In-situ' gel drug delivery is a good approach to achieve sustained release for once-daily administration that will prolong drug retention time at the stomach and increase absorption. Thus, the aim of the study is to formulate floating in-situ gel formulations of metoprolol succinate using Khaya gum ('Khaya senegalensis', family 'Meliaceae') as a polymer. Khaya gum was characterized and used in formulating in situ gels of metoprolol succinate in comparison with Hydroxyl Propyl Methyl Cellulose (HPMC K15M) and Xanthan gum. The 'in-situ' gel formulations were characterized for appearance, swelling, 'in- vitro' buoyancy and in-vitro drug release. FTIR revealed major peaks characteristic of the gum. Khaya gum showed high swelling and good flow properties. In-situ gel formulations of metoprolol succinate containing Khaya were light brown with near neutral pH, higher swelling and a total floating time >24 h, comparable to those containing HPMC and Xanthan gums. Dissolution time t80 was 60.50 to >240 min with ranking Khaya <HPMC <Xanthan. Khaya gum provides a cheaper, suitable polymer for formulating floating in-situ gels with prolonged buoyancy and drug release.