Suppression of acute inflammation with liposome associated prostaglandin E1

Prostaglandin E1 (PGE1) suppresses leucocyte effector function and reduces inflammation in several animal models of acute and chronic inflammation. A drawback to its use as a therapeutic agent is the relatively high doses needed to suppress inflammation. We present evidence in this report that lipos...

Full description

Saved in:
Bibliographic Details
Published inProstaglandins Vol. 48; no. 3; pp. 187 - 195
Main Authors Rossetti, R G, Brathwaite, K, Zurier, R B
Format Journal Article
LanguageEnglish
Published United States 01.09.1994
Subjects
Acute Disease
Animals
Dinoprostone - therapeutic use
Inflammation - drug therapy
Interleukin-1 - physiology
Liposomes
Male
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha - physiology
Online AccessGet full text

Cover

More Information
Summary:Prostaglandin E1 (PGE1) suppresses leucocyte effector function and reduces inflammation in several animal models of acute and chronic inflammation. A drawback to its use as a therapeutic agent is the relatively high doses needed to suppress inflammation. We present evidence in this report that liposome associated PGE1 (LAP) reduces markedly acute inflammation induced in a subcutaneous air pouch by monosodium urate crystals, and by the polypeptide mediators, interleukin 1-beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha). A single dose of 12 micrograms/kg LAP given intravenously 2 hr after inflammation was induced, reduced accumulation of cells and exudate by 31-49%.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0090-6980
DOI:10.1016/0090-6980(94)90018-3