Increased leucine-rich repeats and immunoglobulin- like domains 1 expression enhances chemosensitivity in glioma

• Published in: 中国神经再生研究（英文版） Vol. 6; no. 32; pp. 2516 - 2520
• Main Author: Baohui Liu Qianxue Chen Daofeng Tian Licluan Wu Junmin Wang Qiang Cai Heng Shen Baowei Ji Long Wang Shenqi Zhang Dong Ruan Xiaonan Zhu Zhentao Guo Huimin Dong Mingmin Yan
• Format: Journal Article
• Language: English
• Published: Department of Neurosurgery,Renmin Hospital,Wuhan University,Wuhan 430060,Hubei Province,China%Department of Neurology,Renmin Hospital,Wuhan University,Wuhan 430060,Hubei Province,China 15.11.2011
• Subjects: Bcl-2; 免疫球蛋白; 化疗; 富含亮氨酸重复序列; 敏感性; 结构域; 脑胶质瘤; 锰超氧化物歧化酶; astrocytoma; chemosensitivity; Leucine-rich repeats and immunoglobulin-like domains 1
• ISSN: 1673-5374
• DOI: 10.3969/j.issn.1673-5374.2011.32.007

Leucine-rich repeats and immunoglobulin-like domains 1 （LRIG1） is an anti-oncogene. LRIG1 is correlated with Bcl-2 in ependymomas. Decreased Bcl-2 and manganese superoxide dismutase expression can improve the chemosensitivity of glioma. In the present study, a tissue microarray of human brain astrocytomas was constructed. To investigate the relationship of LRIG1 with Bcl-2 and manganese superoxide dismutase, LRIG1, Bcl-2 and manganese superoxide dismutase expression in our tissue microarray was determined using immunohistochemistry. In addition, we constructed the LRIG1-U251 cell line, and its responses to doxorubicin and temozolomide were detected using the MTT assay. Results showed that LRIG1 expression was significantly negatively correlated with Bcl-2 and manganese superoxide dismutase expression in glioma. Also, proliferation of LRIG1-U251 cells exposed to doxorubicin or temozolomide was significantly inhibited, i.e. in the LRIG1-U251 cell line, the chemosensitivity to doxorubicin and temozolomide was increased. This indicates that increased LRIG1 expression produces a chemosensitivity in glioma.