Type 2 innate lymphoid cells expressing death receptor 3 are increased in airway of mild atopic asthmatic subject following allergen inhalation challenge

To understand novel mechanisms of ILC2 activation, we investigated the role of death receptor 3 (DR3) and its cognate ligand, tumor necrosis factor like protein 1A (TL1A) in mediating ILC2 activation in allergic asthmatic responses. All subjects developed allergen induced dual bronchoconstriction, a...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB285
Main Authors Machida, Kentaro, Baatjes, Adrian, Watson, Richard, Scime, Tara, Gauvreau, Gail M., O'Byrne, Paul M., Sehmi, Roma
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Allergens
Asthma
Atopy
Inhalation
Lymphoid cells
Respiration
Respiratory tract
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Summary:To understand novel mechanisms of ILC2 activation, we investigated the role of death receptor 3 (DR3) and its cognate ligand, tumor necrosis factor like protein 1A (TL1A) in mediating ILC2 activation in allergic asthmatic responses. All subjects developed allergen induced dual bronchoconstriction, airway eosinophilia and increased methacholine airway responsiveness.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.908