Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets

Modern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA) are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A numbe...

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Published inSovremennai͡a︡ revmatologii͡a Vol. 8; no. 2; pp. 71 - 75
Main Author Korotaeva, T.V.
Format Journal Article
LanguageEnglish
Russian
Published IMA-PRESS LLC 08.05.2014
Subjects
ангиогенез
иммунологические механизмы
проангиогенные цитокины
псориаз
псориатический артрит
факто- ры роста
фактор некроза опухоли α
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Summary:Modern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA) are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A number of angiogenesis mediators, pro-angiogenic cytokines, growth factors, matrix metalloproteinases, etc. are shown to be involved in progression of neovascularization. The role of tumor necrosis factor α as a key therapeutic target for treatment of psoriasis and PsA is emphasized. Drugs inhibiting some stages of angiogenesis, which are either used in clinical practice or are being developed, are discussed.
ISSN:1996-7012
2310-158X
DOI:10.14412/1996-7012-2014-2-71-75