The role of matrix metalloproteinases in the myocardial remodeling

The main structural event in the development of heart failure is the myocardial remodeling. The extracellular matrix, that was knows as, considered an inert framework of cardiomyocytes, plays an important role in cardiac remodeling. The enzyme system, primarily responsible for the degradation of the...

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Bibliographic Details
Published inCardioSomatika Vol. 11; no. 3; pp. 22 - 28
Main Authors Bazylev, Vladlen V., Kanaeva, Tatyana V.
Format Journal Article
LanguageEnglish
Published Concilium Medicum 25.11.2020
Subjects
matrix metalloproteinases
myocardial remodeling
сhronic heart failure
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Summary:The main structural event in the development of heart failure is the myocardial remodeling. The extracellular matrix, that was knows as, considered an inert framework of cardiomyocytes, plays an important role in cardiac remodeling. The enzyme system, primarily responsible for the degradation of the extracellular matrix, is a matrix metalloproteinases (MMP). This review examines the evidence for the participation of MMP in the myocardial remodeling and recent studies of MMP as prognostic markers. Regulation of induction and/or activation of MMP are potential therapeutic targets.
ISSN:2221-7185
2658-5707
DOI:10.26442/22217185.2020.3.200374