2-Propyl-1H-imidazole-4,5-dicarboxylate acid supported cu/ni/fe/co complexes: synthesis, biological and catalytic evaluation

Herein, we report 2-propyl-1H-imidazole-4,5-dicarboxylate complexes of Cu/Co/Fe/Ni metal ions. The complexes have been characterized using powder X-ray diffraction, FTIR, and mass spectrometry. Thermal gravimetric analysis (TGA) established their thermal stability, enduring temperatures of up to 650...

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Bibliographic Details
Published inJournal of coordination chemistry Vol. 77; no. 15-16; pp. 1887 - 1904
Main Authors Kawad, Mukesh, Sangani, Sagar R., Parmar, Jigneshkumar, Dabhi, Ranjitsinh C., Chauhan, Rishita, Ahmed, Sarfaraz, Ameta, Rakesh Kumar
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 17.08.2024
Taylor & Francis Ltd
Subjects
Aminophenol
Binding
Biomolecules
BSA
Catalytic converters
Chemical synthesis
Copper
DNA
docking
free radical
Free radicals
Imidazole
Iron
Mass spectrometry
Model reduction
Molecular docking
Nitrophenol
reduction
Serum albumin
Thermal analysis
Thermal stability
Thermogravimetric analysis
X ray powder diffraction
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Summary:Herein, we report 2-propyl-1H-imidazole-4,5-dicarboxylate complexes of Cu/Co/Fe/Ni metal ions. The complexes have been characterized using powder X-ray diffraction, FTIR, and mass spectrometry. Thermal gravimetric analysis (TGA) established their thermal stability, enduring temperatures of up to 650 °C. The interaction of Bovine Serum Albumin (BSA) and DNA with these complexes was examined, revealing a significant binding affinity up to 70%. Fluorescence quenching experiments also showed the binding of complexes with biomolecules. These interactions were substantiated by molecular docking studies against the proteins 3v03 (BSA) and 1d28 (DNA), shedding light on the essential interactions driving their potential medicinal activity. The Cu complex displayed a notably high GSC score and a substantial area as determined through the Patch Dock server. Free radical interaction with 2,2-diphenylpicrylhydrazyl (DPPH) shows their antioxidant activity where Cu and Fe complexes expressed greater activity as compared to others. The catalytic properties of the compounds were assessed using p-nitrophenol (PNP) where the complexes exhibited reducing activity, leading to a conversion of over 90% of PNP into p-aminophenol. Analysis revealed a pseudo-second-order model closely aligned with experimental values, indicating second-order reduction kinetics.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2024.2395894