Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes

(1) The chemotactic activities of thromboxane B2 (TxB2), PGE2, PGF2alpha, the 15-oxo, 15-oxo-13,14-dihydro and 13,14-dihydro metabolites of PGE2, PGF2alpha, and a metabolite of TxB2 for polymorphonuclear leucocytes (PMN) have been investigated. (2) Thromboxane B2 increased the directional migration...

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Published inProstaglandins Vol. 16; no. 2; pp. 239 - 244
Main Authors Kitchen, E A, Boot, J R, Dawson, W
Format Journal Article
LanguageEnglish
Published United States 01.08.1978
Subjects
Animals
Chemotaxis, Leukocyte
Humans
Neutrophils
Prostaglandins - physiology
Prostaglandins E - physiology
Prostaglandins F - physiology
Rats
Thromboxane B2 - physiology
Thromboxanes - physiology
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Summary:(1) The chemotactic activities of thromboxane B2 (TxB2), PGE2, PGF2alpha, the 15-oxo, 15-oxo-13,14-dihydro and 13,14-dihydro metabolites of PGE2, PGF2alpha, and a metabolite of TxB2 for polymorphonuclear leucocytes (PMN) have been investigated. (2) Thromboxane B2 increased the directional migration of rat peritoneal PMN at a concentration of 2.0 micrograms/ml and of human peripheral neutrophils at a concentration of 0.5 microgram/ml. (3) Neither PGE2, PGF2alpha nor their metabolites showed chemotactic activity for rat peritoneal PMN. (4) PGF2alpha and 15-oxo-13,14-dihydro-thromboxane B2 showed no chemotactic activity for human peripheral PMN. (5) The possible role of thromboxane B2 in inflammation is discussed.
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ISSN:0090-6980
DOI:10.1016/0090-6980(78)90025-4