An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence

We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain react...

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Bibliographic Details
Published inPolski przeglad chirurgiczny Vol. 89; no. 5; pp. 1 - 5
Main Authors Walczak, Anna, Przybyłowska-Sygut, Karolina, Sygut, Andrzej, Cieślak, Adrianna, Mik, Michał, Dziki, Łukasz, Dziki, Adam, Majsterek, Ireneusz
Format Journal Article
LanguageEnglish
Published Poland 31.10.2017
Subjects
Adult
Case-Control Studies
Chemokine CCL2 - genetics
Colonic Neoplasms - genetics
Female
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Receptors, CCR2 - genetics
Risk Factors
CCR-2
MCP-1
colorectal cancer
single nucleotide polymorphisms
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Summary:We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
ISSN:0032-373X
2299-2847
DOI:10.5604/01.3001.0010.5246