Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway

Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell d...

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Published inEuropean journal of plastic surgery Vol. 45; no. 6; pp. 863 - 871
Main Authors Houschyar, Khosrow Siamak, Borrelli, Mimi R., Rein, Susanne, Tapking, Christian, Popp, Daniel, Palackic, Alen, Puladi, Behrus, Ooms, Mark, Houschyar, Madeline, Branski, Ludwik K., Schmitt, Laurenz, Modabber, Ali, Rübben, Albert, Hölzle, Frank, Yazdi, Amir S.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022
Subjects
Medicine
Medicine & Public Health
Plastic Surgery
Review
Wnt signaling
Carcinoma
Stem cells
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Summary:Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC. Level of evidence: Not gradable.
ISSN:1435-0130
1435-0130
DOI:10.1007/s00238-022-01958-x