Triamino pyrimidines and pyridines as histamine H₄ receptor modulators

Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure–activity relationships evaluated for activity at the H₄ receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the...

Full description

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 21; no. 10; pp. 3113 - 3116
Main Authors Meduna, Steven P, Savall, Brad M, Cai, Hui, Edwards, James P, Thurmond, Robin L, McGovern, Patricia M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Ltd 15.05.2011
Elsevier
Subjects
Biological and medical sciences
histamine
Medical sciences
Miscellaneous
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
pyridines
pyrimidines
structure-activity relationships
H4 histamine receptor
Nitrogen heterocycle
In vitro
Pyrrolidine derivatives
Pyridine derivatives
Pyrimidine
Histamine
Pyridine
Structure activity relation
Affinity
Pyrimidine derivatives
Antagonist
Piperazine derivatives
Histamine H4
Online AccessGet full text

Cover

More Information
Summary:Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure–activity relationships evaluated for activity at the H₄ receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.
Bibliography:http://dx.doi.org/10.1016/j.bmcl.2011.03.017
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.03.017