A new method of research on molecular evolution of proteinase superfamily

The molecular evolutionary tree, also known as a phylogenetic tree, of the serine proteinase superfamily was constructed by means of structural alignment. Three-dimensional structures of proteins were aligned by the SSAP program of Orengo and Taylor to obtain evolutionary distances. The resulting ev...

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Bibliographic Details
Published inChinese science bulletin Vol. 46; no. 7; pp. 578 - 582
Main Authors Sun, Zhirong, Ji, Xinglai, Hu, Shengmin, Wang, Yu, He, Fuchu
Format Journal Article
LanguageEnglish
Published Beijing Springer Nature B.V 01.04.2001
Subjects
Alignment
Evolution
Homology
Molecular evolution
Molecular structure
Phylogeny
Protein engineering
Protein structure
Proteinase
Proteins
Serine proteinase
Structure-function relationships
Topology
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Summary:The molecular evolutionary tree, also known as a phylogenetic tree, of the serine proteinase superfamily was constructed by means of structural alignment. Three-dimensional structures of proteins were aligned by the SSAP program of Orengo and Taylor to obtain evolutionary distances. The resulting evolutionary tree provides a topology graph that can reflect the evolution of structure and function of homology proteinase. Moreover, study on evolution of the serine proteinase superfamily can lead to better understanding of the relationship and evolutionary difference among proteins of the superfamily, and is of significance to protein engineering, molecular design and protein structure prediction. Structure alignment is one of the useful methods of research on molecular evolution of protein.
ISSN:1001-6538
2095-9273
1861-9541
2095-9281
DOI:10.1007/BF02900414