TGF-β1 gene polymorphism in liver graft recipients

Cytokines are known to be important mediators during liver graft outcome and their gene polymorphism could affect the overall expression and secretion of cytokines. In this retrospective study, we analyzed the effect of TGF-β1 polymorphism in 150 liver allograft recipients. Genotyping PCR-SSP were p...

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Published inTransplant immunology Vol. 17; no. 1; pp. 55 - 57
Main Authors Gómez-Mateo, Jorge, Marin, Luis, López-Alvarez, María R., Moya-Quiles, M. Rosa, Miras, Manuel, Marin-Moreno, Isabel, Botella, Carmen, Parrilla, Pascual, Álvarez-López, María R., Muro, Manuel
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2006
Subjects
Acute rejection
Cytokine polymorphism
Graft acceptance
Liver transplant
Liver transplant
Acute rejection
Graft acceptance
Cytokine polymorphism
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Summary:Cytokines are known to be important mediators during liver graft outcome and their gene polymorphism could affect the overall expression and secretion of cytokines. In this retrospective study, we analyzed the effect of TGF-β1 polymorphism in 150 liver allograft recipients. Genotyping PCR-SSP were performed for TGF-β1 gene (codon 10T/C and 25C/G). TGF-β1 polymorphism at codon 10 and 25 correlate borderline with liver graft acceptance and when the combination between codon 10 and 25 was analyzed, it revealed that T/T G/C genotype and the TC haplotype were significantly associated with graft acceptance ( p < 0.05). TGF-β1 high secretor phenotype was also increased in the acute rejection group close to significance ( p = 0.06). In conclusion, these findings show a correlation between TGF-β1 gene polymorphism and liver graft acceptance.
ISSN:0966-3274
1878-5492
DOI:10.1016/j.trim.2006.09.011