Clinical Significance of IgG-rheumatoid Factor in RA Patients

Clinical correlations with IgG-rheumatoid factor (IgG-RF) were evaluated in 41 patients with rheumatoid arthritis (RA). The patients with positive IgG-RF with disease duration of less than two years showed increased levels in ESR, C-reactive protein, serum IgG concentrations and Lansbury's inde...

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Bibliographic Details
Published inOrthopedics & Traumatology Vol. 44; no. 4; pp. 1277 - 1280
Main Authors Tokito, Takeshi, Masuda, Sachio, Kohashi, Yoshihiro, Nakagawa, Satoru
Format Journal Article
LanguageEnglish
Published West-Japanese Society of Orthopedics & Traumatology 1995
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Summary:Clinical correlations with IgG-rheumatoid factor (IgG-RF) were evaluated in 41 patients with rheumatoid arthritis (RA). The patients with positive IgG-RF with disease duration of less than two years showed increased levels in ESR, C-reactive protein, serum IgG concentrations and Lansbury's index, but they had neither extra-articular disorders nor vascular damage. However, four of eight patients with positive IgG-RF with disease duration of over five years had extra-articular disorders and vascular damage (especially interstitial pneumonia). In one early RA patient with positive IgG-RF who showed decreased levels of ESR and C-reactive protein and serum IgG concentrations, a high titer of IgG-RF was revealed over six months and joint damage progressed. In conclusion, we suggested that measurment of IgG-RF is useful in the clinical evaluation of rheumatoid arthritis associated with extra-articular disorders, vascular damage, and joint damage progression.
ISSN:0037-1033
1349-4333
DOI:10.5035/nishiseisai.44.1277