HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients

• Published in: HLA Vol. 104; no. 2; p. e15616
• Main Authors: Andreani, Marco, Mariotti, Feliciana, Pira, Anna, Locatelli, Franco, Testa, Giuseppe, Battarra, Mariarosa, Caputi, Priscilla, Scarabello, Alessandra, Bellei, Barbara, Di Campli, Cristiana, Collina, Maria Chiara, Esposito, Ilaria, Giampetruzzi, Anna Rita, Didona, Biagio, Pitocco, Dario, De Simone, Clara, Di Zenzo, Giovanni
• Format: Journal Article
• Language: English
• Published: England 01.08.2024
• Subjects: Aged; Aged, 80 and over; Alleles; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; HLA-DQ beta-Chains - genetics; Humans; Italy; Male; Middle Aged; Pemphigoid, Bullous - chemically induced; Pemphigoid, Bullous - genetics; Italy; gliptin; HLA‐DQB103:01; bullous pemphigoid
• ISSN: 2059-2310
• DOI: 10.1111/tan.15616

Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.