The Effect of 2-Thiophenecarbocylic Acid (TCA) on Fracture Callus in early stage of HEBP (EHDP) Induced Rachitic Rats

We have already shown that TCA promotes calcification of the thickened growth plate in the healing stage of HEBP-induced rachitic rats respectively. In this experiment female weanling Fisher-344 rats of 4 weeks of age were used and the experiment period was settled to be 2 weeks. Sixty mg/Kg body we...

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Published inOrthopedics & Traumatology Vol. 35; no. 4; pp. 1076 - 1081
Main Authors Ibi, Naotaka, Eguchi, Masao, Shimauchi, Takashi, Kawamura, Hideya, Shibata, Kenichiro, Wada, Fumio, Nakasima, Katuya, Nakaie, Kazuhisa, Kisikawa, Youichi, Matumoto, Kouji
Format Journal Article
LanguageEnglish
Published West-Japanese Society of Orthopedics & Traumatology 1987
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Summary:We have already shown that TCA promotes calcification of the thickened growth plate in the healing stage of HEBP-induced rachitic rats respectively. In this experiment female weanling Fisher-344 rats of 4 weeks of age were used and the experiment period was settled to be 2 weeks. Sixty mg/Kg body weight of HEBP was dosed subcutaneously, daily for the former 7 days and then 200, 400 or 600mg/kg body weight of TCA was given to the each rat of TCA group for the latter 7 days. In the result HEBP+TCA group showed prominent mineralization and calcification of newly formed bone and caltilage of the callus in comparison to rats treated with HEBP alone at 14 days after fracture.
ISSN:0037-1033
1349-4333
DOI:10.5035/nishiseisai.35.1076