Contribution of calcium ion sequestration by polyoxyethylated nonionic surfactants to the enhanced colonic absorption of p-aminobenzoic acid

Enhanced absorption of p-aminobenzoic acid (PABA) from the colon by polyoxyethylated nonionic surfactants was investigated using an in situ perfusion technique. The order of their absorption-enhancing effect was as follows: polyoxyethylene lauryl ether greater than polyoxyethylene sorbitan fatty aci...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 75; no. 4; p. 387
Main Authors Sakai, K, Kutsuna, T M, Nishino, T, Fujihara, Y, Yata, N
Format Journal Article
LanguageEnglish
Published United States 01.04.1986
Subjects
4-Aminobenzoic Acid - metabolism
Aminobenzoates - metabolism
Animals
Calcium - physiology
Colon - metabolism
Epithelium - metabolism
Intestinal Absorption - drug effects
L-Lactate Dehydrogenase - metabolism
Male
Polyethylene Glycols - pharmacology
Proteins - metabolism
Rats
Rats, Inbred Strains
Surface Tension
Surface-Active Agents - pharmacology
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Summary:Enhanced absorption of p-aminobenzoic acid (PABA) from the colon by polyoxyethylated nonionic surfactants was investigated using an in situ perfusion technique. The order of their absorption-enhancing effect was as follows: polyoxyethylene lauryl ether greater than polyoxyethylene sorbitan fatty acid esters approximately equal to polyoxyethylene fatty acid esters. The coexistence of calcium chloride in the perfusing solution caused a partial reverse in this enhancement. The calcium ion sequestration capacity of the surfactants was correlated with their ability to enhance colonic absorption of PABA. The findings suggest that calcium ion sequestration by the surfactants contributes to their enhancement of the colonic absorption of PABA.
ISSN:0022-3549
DOI:10.1002/jps.2600750414