Immunotherapy of colon cancer metastases in rats with the immunostimulant OM-89

• Published in: Anti-cancer drugs Vol. 1; no. 2; p. 143
• Main Authors: Lagadec, P, Onier, N, Bauer, J, Tourne, S, Jeannin, J F
• Format: Journal Article
• Language: English
• Published: England 01.12.1990
• Subjects: Adjuvants, Immunologic - adverse effects; Adjuvants, Immunologic - therapeutic use; Administration, Oral; Animals; Antigens, Bacterial; Ascitic Fluid - therapy; Colonic Neoplasms - secondary; Colonic Neoplasms - therapy; Female; Immunotherapy; Injections, Intraperitoneal; Lipopolysaccharides - administration & dosage; Male; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - therapy; Rats
• DOI: 10.1097/00001813-199012000-00005
• ISSN: 0959-4973

In a model of colon cancer in rats the bacterial extract OM-89 was found to have antitumor properties. We have shown that OM-89 induced the complete regression of numerous peritoneal tumor nodules measuring 1-5 mm in 46% of rats, and inhibited the growth of microscopic tumors in 42% of rats. OM-89 was effective when injected ip at the dose of 50 mg/kg, twice a week for 2 weeks. It was ineffective at the same dose when given orally every day for 14 or 21 days. The traces of endotoxins (0.0005%) were probably not involved in the antitumor effect of OM-89. No side-effects were observed.