Immunotherapy of colon cancer metastases in rats with the immunostimulant OM-89

In a model of colon cancer in rats the bacterial extract OM-89 was found to have antitumor properties. We have shown that OM-89 induced the complete regression of numerous peritoneal tumor nodules measuring 1-5 mm in 46% of rats, and inhibited the growth of microscopic tumors in 42% of rats. OM-89 w...

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Bibliographic Details
Published inAnti-cancer drugs Vol. 1; no. 2; p. 143
Main Authors Lagadec, P, Onier, N, Bauer, J, Tourne, S, Jeannin, J F
Format Journal Article
LanguageEnglish
Published England 01.12.1990
Subjects
Adjuvants, Immunologic - adverse effects
Adjuvants, Immunologic - therapeutic use
Administration, Oral
Animals
Antigens, Bacterial
Ascitic Fluid - therapy
Colonic Neoplasms - secondary
Colonic Neoplasms - therapy
Female
Immunotherapy
Injections, Intraperitoneal
Lipopolysaccharides - administration & dosage
Male
Peritoneal Neoplasms - secondary
Peritoneal Neoplasms - therapy
Rats
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Summary:In a model of colon cancer in rats the bacterial extract OM-89 was found to have antitumor properties. We have shown that OM-89 induced the complete regression of numerous peritoneal tumor nodules measuring 1-5 mm in 46% of rats, and inhibited the growth of microscopic tumors in 42% of rats. OM-89 was effective when injected ip at the dose of 50 mg/kg, twice a week for 2 weeks. It was ineffective at the same dose when given orally every day for 14 or 21 days. The traces of endotoxins (0.0005%) were probably not involved in the antitumor effect of OM-89. No side-effects were observed.
ISSN:0959-4973
DOI:10.1097/00001813-199012000-00005