Onset of chromosome segregation at the metaphase to anaphase transition of the cell cycle

Chromosome segregation is one of the most important acts in the life of the cell. Unequal inheritance of chromosomes (aneuploidy) is a cause of a number of disorders, particularly in humans, even though eukaryotic cells can arrest or delay the transition from metaphase to anaphase if an event critic...

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Bibliographic Details
Published inProgress in cell cycle research Vol. 1; p. 309
Main Authors Dorée, M, Le Peuch, C, Morin, N
Format Journal Article
LanguageEnglish
Published France 1995
Subjects
Anaphase
Animals
Cell Cycle
Chromosomes - physiology
DNA Topoisomerases, Type II - physiology
Metaphase
Microtubules - physiology
Mitosis
Mutation
Sister Chromatid Exchange
Ubiquitins - pharmacology
Xenopus
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Summary:Chromosome segregation is one of the most important acts in the life of the cell. Unequal inheritance of chromosomes (aneuploidy) is a cause of a number of disorders, particularly in humans, even though eukaryotic cells can arrest or delay the transition from metaphase to anaphase if an event critical to the completion of metaphase is impaired. In this report, we review recent advances in our knowledge of how the complex process of chromosome segregation is coupled with cell cycle progression, and starts at onset of anaphase with sister chromatids separation of the replicated chromosomes.
ISSN:1087-2957
DOI:10.1007/978-1-4615-1809-9_25