Diffuse skin erythematous plaque as a manifestation of epithelioid hemangioendothelioma: A case report

• Published in: Heliyon Vol. 10; no. 18; p. e37732
• Main Authors: Pan, Ruoxin, Wang, Chuang, Gu, Duoduo, Meng, Xiaoqi, Liu, Tingwei, Zhong, Hui, Gong, Qixing, Xu, Yang
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2024; Elsevier
• Subjects: Case report; Epithelioid hemangioendothelioma; Skin neoplasms; WWTR1-CAMTA1; Epithelioid hemangioendothelioma; Case report; WWTR1-CAMTA1; Skin neoplasms
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e37732

Epithelioid hemangioma (EHE) is a rarely malignant tumor originating from the vascular endothelium. Morphological manifestations and immunohistochemical staining results are key to diagnosing EHE. Herein, we present a case of cutaneous involment in a recurrence of EHE. A 75-year-old woman presented with a month-long history of persistent erythematous plaque and pain in the left shoulder. Skin biopsy specimen revealed epithelioid tumor cells containing abundant eosinophilic cytoplasm. Immunohistochemical staining confirmed a recurrence of EHE involving the skin. Subsequently, recombinant human endostatin was administered. At the 10-day follow-up, the cutaneous plaque had improved, and the pain had resolved. When presenting as a local painful erythematous plaque, the possibility of skin involvement in a malignant tumor should be considered. Early diagnosis and early systemic therapy have an important impact on the overall survival of patients with EHE. •Epithelioid hemangioendothelioma is a malignant tumor of the vascular endothelium. Morphological manifestations and immunohistochemical staining results are the key to the diagnosis of EHE.•We noted a recurrence of soft tissue EHE involving the skin, manifesting as carcinoma erysipeloides. The possibility of skin involvement in malignant tumor should be considered when patients present with a locally painful erythematous plaque.•Epithelioid hemangioendothelioma with cutaneous involvement often has a poor prognosis and systemic therapy should be initiated at the earliest.