Preparation and in vitro evaluation of GdDOTA-(BOM)4; a novel angiographic MRI contrast agent

A novel Gd(III) complex, GdDOTA-(BOM)4, has been prepared by a simple three-step procedure. The complex showed high T1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T1-relaxivity in plasma, 67.4 s-1 mM-1 (20 MHz, 37 degrees C), ma...

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Published inOrganic & biomolecular chemistry Vol. 1; no. 10; pp. 1707 - 1710
Main Authors Hovland, Ragnar, Aasen, Arne J, Klaveness, Jo
Format Journal Article
LanguageEnglish
Published England 21.05.2003
Subjects
Angiography - methods
Animals
Cattle
Contrast Media - chemical synthesis
Contrast Media - chemistry
Contrast Media - metabolism
Gadolinium - chemistry
Heterocyclic Compounds, 1-Ring - chemistry
Humans
Magnetic Resonance Imaging - methods
Organometallic Compounds - blood
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Protein Binding
Serum Albumin, Bovine - metabolism
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Summary:A novel Gd(III) complex, GdDOTA-(BOM)4, has been prepared by a simple three-step procedure. The complex showed high T1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T1-relaxivity in plasma, 67.4 s-1 mM-1 (20 MHz, 37 degrees C), makes it a promising candidate for angiographic applications of MRI.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/b301944f