Direct electrochemical detection of PCR product based on charge transfer through DNA

Human genome project and genetic identification for inherited diseases will definitely have a profound impact on the diagnosis of diseases, which calls for rapid and accurate assays of DNA. Among different types of sensors, electrochemical DNA biosensors offer a promising alternative meanst. Recent...

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Bibliographic Details
Published inChinese science bulletin Vol. 50; no. 15; pp. 1666 - 1668
Main Author ZHAO Hongtao ZHANG Zhijie JU Huangxian
Format Journal Article
LanguageEnglish
Published Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing 210093, China 01.08.2005
Subjects
DNA
基因组
生物传感器
遗传疾病
遗传表达
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Summary:Human genome project and genetic identification for inherited diseases will definitely have a profound impact on the diagnosis of diseases, which calls for rapid and accurate assays of DNA. Among different types of sensors, electrochemical DNA biosensors offer a promising alternative meanst. Recent efforts to elucidate the mechanism of charge transfer in DNA have demonstrated that the charge transfer is sensitive to the perturbation in base stackt.
Bibliography:11-1785/N
R394
ISSN:1001-6538
1861-9541
DOI:10.1360/982005-684