Growth and skeletal maturation in children with type 1 diabetes mellitus
Objective: To study growth and skeletal maturation in children with type 1 diabetes mellitus (T1DM). Methods: We prospectively studied the anthropometric data of 56 children with T1DM at our tertiary care teaching hospital. Height was re-measured at one year to assess height velocity. A plain radiog...
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Published in | Journal of Clinical and Scientific Research Vol. 5; no. 1; pp. 20 - 27 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Wolters Kluwer Medknow Publications
2016
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Subjects | |
Online Access | Get full text |
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Summary: | Objective: To study growth and skeletal maturation in children with type 1 diabetes mellitus (T1DM). Methods: We prospectively studied the anthropometric data of 56 children with T1DM at our tertiary care teaching hospital. Height was re-measured at one year to assess height velocity. A plain radiograph of the left hand was obtained for assessment of skeletal maturation. Glycosylated haemoglobin and thyroid stimulating hormone were measured in all the patients. Results: Short stature [height standard deviation score (HtSDS) <–2] was seen in 15/56 (27%) patients. A negative correlation was observed between HtSDS at recruitment and duration of T1DM (r = –0.347, p = 0.009). Ten of the 25 patients followed up over one year had impaired (< 3rd centile) height velocity (HV). A negative correlation was observed between glycosylated haemoglobin (r = –0.664, p=<0.001) and HV. The proportion of patients with an impaired HV was more in those with an age of onset more than 7.5 yrs (42% Vs 14%, p=0.005). A delayed bone age was observed in 10/37 (27%) patients assessed for skeletal maturation. It correlated negatively with the body mass index standard deviation score (r = –0.484, p=0.002). Conclusion: Poor glycaemic control causes impaired growth in patients with T1DM. Further, T1DM may also be associated with delayed skeletal maturation. |
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ISSN: | 2277-5706 2277-8357 |
DOI: | 10.15380/2277-5706.JCSR.15.059 |