Oxidative Modification of Rat Blood Proteins after Lesioning of Capsaicin-Sensitive Nerves and Changes in Nitric Oxide Levels
Oxidative modification of blood proteins in rats after lesioning of afferent nerves with capsaicin (150 mg/kg, s.c.) and changes in nitric oxide (NO) contents were studied in terms of levels of protein carbonyl derivatives. Deafferentation of capsaicin-sensitive nerves induced increases in the level...
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Published in | Neuroscience and behavioral physiology Vol. 41; no. 5; pp. 479 - 483 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.06.2011
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Oxidative modification of blood proteins in rats after lesioning of afferent nerves with capsaicin (150 mg/kg, s.c.) and changes in nitric oxide (NO) contents were studied in terms of levels of protein carbonyl derivatives. Deafferentation of capsaicin-sensitive nerves induced increases in the level of protein carbonyl derivatives. Increases in NO levels using L-arginine did not alter measures of the oxidative modification of proteins after lesioning of capsaicin-sensitive innervation. A similar lack of effect was seen after blockade of neuronal NO synthase (n-NOS) by the selective inhibitor 7-nitroindazole (7-NI). Increases in markers of oxidative destruction of proteins in capsaicin-treated animals were seen after blockade of NO synthesis by the nonselective inhibitor L-NAME. These results show that deafferentation of capsaicin-sensitive nerves induces oxidative modification of proteins and that this process involves NO. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0097-0549 1573-899X |
DOI: | 10.1007/s11055-011-9440-7 |