In vivo accumulation of sodium pump inhibitor by normal and uremic erythrocytes

A uremic toxin fraction (fraction 2-3-1) in the middle molecular mass range (300-2000 Da) containing a sodium potassium inhibitor pump was studied. As fraction 2-3-1 was known to be present in minute quantities in urine and plasma, erythrocyte lysates were used as an alternative source. Results show...

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Bibliographic Details
Published inInternational journal of artificial organs Vol. 16; no. 3; p. 120
Main Authors Gallice, P, Lai, E, Brunet, P, Berland, Y, Elsen, R, Crevat, A
Format Journal Article
LanguageEnglish
Published United States 01.03.1993
Subjects
Chromatography, Gel
Chromatography, Ion Exchange
Erythrocytes - metabolism
Humans
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Toxins, Biological - blood
Toxins, Biological - pharmacology
Uremia - blood
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Summary:A uremic toxin fraction (fraction 2-3-1) in the middle molecular mass range (300-2000 Da) containing a sodium potassium inhibitor pump was studied. As fraction 2-3-1 was known to be present in minute quantities in urine and plasma, erythrocyte lysates were used as an alternative source. Results show that fraction 2-3-1 is more abundant in erythrocytes than in normal urine. In addition, the fraction is present in a greater quantity in uremic erythrocytes than in normal blood cells. It is concluded that fraction 2-3-1 is concentrated at the erythrocyte level in uremic patients.
ISSN:0391-3988
DOI:10.1177/039139889301600302