Evaluation of the antibacterial activity of zinc oxide nanoparticles doped with copper ions and co-doped with copper and silver ions

The current feasibility study deals with the elimination of Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) bacterial strains isolated from swimming pools using zinc oxide (ZnO) nanoparticles (NPs) doped with copper (Cu2+) ions (CuX%/ZnO NPs) and co-doped with copper (Cu2+...

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Published inMain group chemistry Vol. 21; no. 4; pp. 1131 - 1150
Main Authors Nohegar, Shadi Ashraf, Nejaei, Arazoo, Fataei, Ebrahim, Ramezani, Mohammad Ebrahim, Eslami, Parvin Alizadeh
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2022
IOS Press BV
Subjects
Bacteria
Copper
E coli
Electron microscopy
Feasibility studies
Field emission microscopy
Gram-positive bacteria
Microscopy
Nanoparticles
Silver
Sol-gel processes
Swimming pools
Zinc oxide
Zinc oxides
antibacterial activity
Zinc oxide nanoparticle
doped and co-doped nanoparticle
Agar well diffusion
photocatalytic activity
sol-gel
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Summary:The current feasibility study deals with the elimination of Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) bacterial strains isolated from swimming pools using zinc oxide (ZnO) nanoparticles (NPs) doped with copper (Cu2+) ions (CuX%/ZnO NPs) and co-doped with copper (Cu2+) and silver (Ag+) ions (AgX%/CuY%/ZnO NPs) synthesized by sol-gel method. Antibacterial activity was evaluated by Agar well diffusion assay. As-produced NPs were characterized by X-ray diffraction, Field emission-scanning electron microscopy, Energy Dispersive X-Ray and Transmission electron microscopy techniques. The results showed that the size of the co-doped NPs was smaller than that of mono-doped NPs. Meanwhile, co-doped Ag5%/Cu5%/ZnO NPs had the maximum bactericidal activity, and the destructive effect on Gram-positive bacteria was greater than that on Gram-negative bacteria. The lowest effective nanoparticle concentrations were 0.1 and 0.05 g/mL. The main bactericidal mechanism, in addition to the size of co-doped NPs, was due to the formation of reactive oxygen species, so that the destruction of the bacterial cell wall and finally death occurred through the radicals formed.
ISSN:1024-1221
1745-1167
DOI:10.3233/MGC-220098