Adult medulloblastoma following fractionated proton therapy for acoustic neuroma

Introduction: Radiation-induced medulloblastoma is exceedingly rare. Four cases of adult medulloblastoma were previously reported to have occurred following whole brain or craniospinal irradiation. Development of systemic malignancies secondary to proton beam therapy is extremely uncommon, with a li...

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Published inJournal of radiation oncology Vol. 2; no. 1; pp. 113 - 118
Main Authors Jabbour, Mark N., Geara, Fady B., Hourani, Roula, Adada, Badih, Rebeiz, Jean G., Ahdab-Barmada, Mamdouha
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.03.2013
Subjects
Cancer Research
Case Report
Imaging
Medicine
Medicine & Public Health
Oncology
Radiology
Radiotherapy
Surgery
Surgical Oncology
Brain radiation necrosis
Proton beam radiotherapy
Radiation-induced neoplasms
Medulloblastoma
Vestibular schwannoma
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Summary:Introduction: Radiation-induced medulloblastoma is exceedingly rare. Four cases of adult medulloblastoma were previously reported to have occurred following whole brain or craniospinal irradiation. Development of systemic malignancies secondary to proton beam therapy is extremely uncommon, with a lifetime risk lower than 1 %. Methods and Results: A 39-year-old woman presented with gait instability and a right cerebellar mass following an 8-year latency period post-fractionated proton therapy for an acoustic neuroma. To date, no cases of new onset medulloblastoma have been reported following proton beam therapy. The differential diagnosis by imaging studies includes brain radiation necrosis. Conclusion: The current report highlights the possible, although rare, risks and complications associated with proton beam radiation. Further studies are needed to address issues related to the management and treatment of radiation-induced medulloblastomas.
ISSN:1948-7894
1948-7908
DOI:10.1007/s13566-012-0080-5