Inhibitory effect of arsenic on aerobic gut flora in rat

An in vivo study was carried on rats to see the influence of arsenic on aerobic gut flora. A significant inhibition of gut flora was observed after 2 weeks of administration of arsenic (1 mg/L) ad libitum with a decrease in stool arsenic level and increase in liver arsenic level. However, this inhib...

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Published inBangladesh Medical Research Council bulletin Vol. 35; no. 3; pp. 79 - 83
Main Authors Choudhry, Zubaida Khatoon, Misbahuddin, Mir, Hosain, A K M Mosharrof, Saleh, Ahmed Abu
Format Journal Article
LanguageEnglish
Published Bangladesh 01.12.2009
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Arsenic - pharmacology
Bacteria, Aerobic - drug effects
Gastrointestinal Tract - drug effects
Gastrointestinal Tract - microbiology
Male
Rats
Rats, Long-Evans
Streptomycin - pharmacology
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Summary:An in vivo study was carried on rats to see the influence of arsenic on aerobic gut flora. A significant inhibition of gut flora was observed after 2 weeks of administration of arsenic (1 mg/L) ad libitum with a decrease in stool arsenic level and increase in liver arsenic level. However, this inhibitory effect of arsenic on gut flora was not observed in presence of vitamin E (1 mg/day) or selenium (0.4 microg/day). Pretreatment with streptomycin (500 mg twice daily) showed similar results. Rats that received folic acid (200 microg/day) showed inhibition of gut floral count but there were decreased liver arsenic level.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0377-9238
2224-7238
DOI:10.3329/bmrcb.v35i3.4205