Formulation and quality evaluation of Coriander Triphala tablet

• Published in: Journal of medicinal plants (Online) Vol. 20; no. 78; pp. 68 - 77
• Main Authors: Choopani, Rasool, Hajimehdipoor, Homa, Molaei, Karam, Kashafroodi, Haniye, Tavakolifar, Fatemeh, Ara, Leila
• Format: Journal Article
• Language: English
• Published: Institue of Medicinal Plants, ACECR 01.05.2021
• Subjects: coriander triphala; formulation; iranian traditional medicine; quality control; tablet
• ISSN: 2717-204X; 2717-2058
• DOI: 10.52547/jmp.20.78.68

Background: Coriander Triphala is one of the famous drugs in traditional medicine which is consisted of Terminalia chebula, T. bellirica, Phyllanthus emblica, Coriandrum sativum, almond oil and honey. Traditional dosage forms should be converted to modern forms for better acceptance and suitable characteristics and stability. Objective: In the present investigation, the traditional form of Coriander Triphala was converted to film coated tablet and quality control of the tablet was performed. Methods: The fruits of T. chebula, T. bellirica, Ph. emblica, C. sativum in equal proportions along with almond oil and honey in different proportions were used for tablet formulation with other excipients. Sixteen formulations were made and after pre-formulation studies, twelve of them were selected for making tablet. Prepared tablets went through primary quality control tests such as weight variation, friability, hardness and disintegration time. Finally, the best formulation was coated by green colored water soluble material and its physicochemical characteristics were determined. Results: Among different formulations, the tablet consisted of 98 mg of each species, 14 mg almond oil, 148 mg honey along with lactose, Avicel PH-102, croscarmellose sodium, PVP K30, magnesium stearate and silicone dioxide was the best one. Weight variation, hardness, disintegration time, total tannins content as pyrogallol were found 1192 mg ± 5 %, 20 kp, 25 min and 64.19 mg/tablet, respectively. Over 90 % of tannins were released after 60 min during dissolution test. Conclusion: The formulated tablet with suitable characteristics is a good substitution for traditional form and could be produced in industrial scale after complementary clinical trial studies.