Postictal disorders of heart rate regulation and functional capabilities of heart in status epilepticus

The objective of the study was to investigate the mechanisms of the autonomic regulation of heart and its functional capacity at different periods after the status epilepticus, and to assess the risk of life-threatening arrhythmias. Methods. The work was carried out on male Wistar rats, weighing 280...

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Bibliographic Details
Published inRomanian journal of neurology Vol. 17; no. 2; pp. 99 - 105
Main Authors Mamalyga, M.L., Mamalyga, L.M., Sychev, V.V.
Format Journal Article
LanguageEnglish
Published Amaltea Medical Publishing House 30.06.2018
Subjects
arrhythmias
ecg
functional capabilities of heart
heart rate variability
status epilepticus
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Summary:The objective of the study was to investigate the mechanisms of the autonomic regulation of heart and its functional capacity at different periods after the status epilepticus, and to assess the risk of life-threatening arrhythmias. Methods. The work was carried out on male Wistar rats, weighing 280–320 g. The following methods were used to study: telemetry monitoring ECG and EEG, echocardiography, functional tests. Results. Analysis of changes in autonomic regulation of heart after SE revealed the inadequacy of compensatory mechanisms that fail to prevent cardiac dysfunctions that reduce the functional capacity of heart and increase the risk of fatal ventricular arrhythmias, which are predictors of sudden cardiac death. Conclusions. High degree of seizure activity of brain in SE predetermines secondary postictal complications in the form of prolonged disorders of autonomic regulation of heart, which increases its vulnerability, limits restorative capacity and can become a pathogenetic basis for severe cerebrocardial disorders.
ISSN:1843-8148
2069-6094
DOI:10.37897/RJN.2018.2.7