Effect of E3810, a proton pump inhibitor, on gastric acid secretion

• Published in: Japanese Journal of Pharmacology Vol. 49; no. suppl; p. 118
• Main Authors: Shibata, Hisashi, Fujisaki, Hideaki, Oketani, Kiyoshi, Fujimoto, Masatoshi, Wakabayashi, Tsuneo, Yamatsu, Isao
• Format: Journal Article
• Language: English; Japanese
• Published: The Japanese Pharmacological Society 1989

The effect of E3810, a new proton pump inhibitor, on the gastric acid secretion was studied in comparison with omeprazole. The intraduodenal administration of E3810 in chronic gastric fistula dogs dose-dependently inhibited gastric acid secretion induced by histamine. The ED50 was 60 μg/kg, which co...