Effect of E3810, a proton pump inhibitor, on gastric acid secretion

• Published in: Japanese Journal of Pharmacology Vol. 49; no. suppl; p. 118
• Main Authors: Shibata, Hisashi, Fujisaki, Hideaki, Oketani, Kiyoshi, Fujimoto, Masatoshi, Wakabayashi, Tsuneo, Yamatsu, Isao
• Format: Journal Article
• Language: English; Japanese
• Published: The Japanese Pharmacological Society 1989
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)56198-4

The effect of E3810, a new proton pump inhibitor, on the gastric acid secretion was studied in comparison with omeprazole. The intraduodenal administration of E3810 in chronic gastric fistula dogs dose-dependently inhibited gastric acid secretion induced by histamine. The ED50 was 60 μg/kg, which corresponded to a potency 2 times greater than that of omeprazole. After a single dose of omeprazole. which produced total inhibition, more than 50% inhibition remained after 24 hr and significant inhibition was still observed after 48 hr. E3810 produced a slight inhibitory effect 24 hr after administration, but no significant inhibition at 48 hr. E3810 was more potent but the duration of the antisecretory effect was shorter than that of omeprazole. After 7 days of treatment with E3810 and omeprazole, gastric acid secretion was recovered to the initial level 2 days and 3 days later, respectively. At the end of one week of treatment, there was a significant rise of plasma gastrin with omeprazole but not with E3810. These results show that E3810 should be useful for the treatment of peptic ulcers.