Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia

• Published in: Hematology, Transfusion and Cell Therapy
• Main Authors: Abobakr, Asmaa, Osman, Randa A, Kamal, Mohamed A M, Abdelhameed, Sayed Abed, Ismail, Hagar H, Kamel, Mahmoud M, Alsharif, Khalaf F, Hamad, Nema R
• Format: Journal Article
• Language: English
• Published: Brazil 06.12.2023
• Subjects: CD27; TEL/AM; CD44; MRD; BCP-ALL
• ISSN: 2531-1379; 2531-1387
• DOI: 10.1016/j.htct.2023.10.003

The expression pattern of CD27 and CD44 was found to correlate with the differentiation stages of B cell precursors, which were known to be involved in a variety of immunological responses. This study aimed to determine the biological significance of CD27 and CD44 expression in patients with B-precursor acute lymphoblastic leukemia (B-ALL), as well as their association with standard prognostic factors and therapeutic response. This case-control study included 60 pediatric patients newly diagnosed with B-ALL and 30 pediatric controls. The patient CD27 and CD44 levels were measured using the Beckman Coulter Navios Flow Cytometer. Most malignant cells (91.6 %) expressed CD44, but only 50 % of the patients had CD27 expressed. The positive CD 44 expression was associated with unfavorable prognostic markers, including a decrease.