Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors

Adoptive cell transfer (ACT) shows significant efficacy against hema-tological malignancies but is limited in solid tumors due to poor homing, immunosuppre-ssion, and potential toxicity. Biomaterials spanning from nano- to macroscales-including nanoparticles, microspheres/micropatches, and hydrogels...

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Published inZhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban Vol. 54; no. 4; pp. 469 - 478
Main Authors CHEN, Jiaxin, LIU, Rui, TANG, Yingqi, QIAN, Chenggen
Format Journal Article
LanguageChinese
English
Published China 15.07.2025
Subjects
Adoptive Transfer - methods
Animals
Biocompatible Materials - chemistry
Humans
Hydrogels
Immunotherapy, Adoptive - methods
Nanoparticles
Neoplasms - therapy
Tumor microenvironment
Adoptive cell transfer
Drug delivery
Review
Chimeric antigen receptor T cell therapy
Immune cells
Biomaterials
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Summary:Adoptive cell transfer (ACT) shows significant efficacy against hema-tological malignancies but is limited in solid tumors due to poor homing, immunosuppre-ssion, and potential toxicity. Biomaterials spanning from nano- to macroscales-including nanoparticles, microspheres/micropatches, and hydrogels-offer unique advantages for cell engineering, delivery, and modulation of the tumor microenvironment. Specifically, nanoparticles enable gene delivery, artificial antigen-presenting cell engi-neering, and immune microenvironment remodeling. Microspheres/micropatches improve immune cell expansion, targeted activation, and localized retention. Hydrogels enhance ACT via genetic engineering, 3D culture support, and cytokine co-delivery. This review summarizes advances in biomaterial-enhanced ACT, highlighting their potential to improve delivery efficiency, amplify antitumor responses, and reduce toxicity. These insights may accelerate the clinical translation of ACT for solid tumors.
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ISSN:1008-9292
DOI:10.3724/zdxbyxb-2024-0651