Cutaneous immunity and predisposition to infections in diabetic foot population

It is unanimously accepted that patients with diabetes have a higher likelihood for infections. The metabolic imbalance associated with diabetes suppresses the immunity system of the cutaneous organ. Hyperglycemia causes an increase of the activity of the sorbitol route with consumption of NADPH. Fu...

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Bibliographic Details
Published inRevista medicală Română Vol. 67; no. 2; pp. 113 - 116
Main Authors Andrei, Pavelina Mihaela, Tanasescu, Maria Daniela, Minca, Alexandru, Balcangiu-Stroescu, Andra-Elena, Balan, Daniela, Mihai, Andrada, Limbau, Alexandra Maria, Ionescu Tirgoviste, Constantin
Format Journal Article
LanguageEnglish
Published Amaltea Medical Publishing House 30.06.2020
Subjects
hyperglycemia
immune response
infections
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Summary:It is unanimously accepted that patients with diabetes have a higher likelihood for infections. The metabolic imbalance associated with diabetes suppresses the immunity system of the cutaneous organ. Hyperglycemia causes an increase of the activity of the sorbitol route with consumption of NADPH. Furthermore, the sorbitol from the cells leads to increase of osmolality in cells as well as reduction of intracellular myo-inositol. These strains on the cellular metabolism expose the cells to oxidative stress. An additional factor is the reduced chemotaxis and phagocytosis impact on the bacterial activity of leukocytes which leads to further predisposition of infection for diabetes patients. Hence the poor control of glycemic levels leads to immunity changes which affects the local immune response against the aggression of pathogenic agents.
ISSN:1220-5478
2069-606X
DOI:10.37897/RMJ.2020.2.1