Therapeutic efficacy of cefquinome against acute respiratory disease in Holstein steers

• Published in: Journal of the Japan Veterinary Medical Association Vol. 54; no. 6; pp. 451 - 454
• Main Authors: Funaki, H. (Obihiro Univ. of Agriculture and Veterinary Medicine, Hokkaido (Japan)), Uzuka, Y, Tanabe, S, Iwahara, K, Takaichi, Y, Kusano, K, Sarashina, T
• Format: Journal Article
• Language: Japanese; English
• Published: Japan Veterinary Medical Association 20.06.2001
• Subjects: ACUTE COURSE; acute respiratory disease; BULLOCKS; cefquinome; DRUG THERAPY; P. multocida; Pasteurella haemolytica; RESPIRATORY DISEASES; steer
• ISSN: 0446-6454; 2186-0211
• DOI: 10.12935/jvma1951.54.451

Eighty Holstein steers affected with acute respiratory diseases were treated intramuscularly with cefquinome, a fourth-generation cephem antibiotic with a short withdrawal period. Therapeutic effects were compared with those of ceftiofur, a third-generation cephem antibiotic, by the clinical and microbiological standpoints. Pasteurella multocida and/or P. haemolytica, known to be major causative organisms in acute bovine respiratory diseases, were isolated from these steers. No difference was observed in antibiotic therapeutic effects between diseases caused by Pasteurella spp. and those caused by other bacteria. Cefquinome had a 98.1% clinical efficacy, which is comparable to that of ceftiofur. At reexammation performed 7 days after final administration, no clinical recurrence was observed.