Effects of Cilostazol on experimental thrombosis in the swine carotid artery

• Published in: Japanese Journal of Pharmacology Vol. 76; no. suppl.1; p. 173
• Main Authors: Kohda, Noriyuki, Nakayama, Sunao, Tani, Takeshi, Kimura, Yukio
• Format: Journal Article
• Language: English
• Published: The Japanese Pharmacological Society 1998
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)40802-0

Thrombus formation in the carotid artery(CA) plays an important role in the pathogenesis of trensient ischemic attack(TIA) and stroke. In this study, the inhibitory effects of cilostazol, an anti-platelet agent, on intraluminal thrombi induced by electrical stimulation in the CA of swine were compared with that of ticlopidine. Cilostazol(30mg/kg/day for 2days) significantly prolonged time to total occlusion (TTO)(215±41.2 min vs. control 133.4±65.0 min, p<0.05), with concomitant platelet aggregation(PA) inhibition ex vivo. In the ticlopidine group (50 mg/kg b.i.d., for 3 days), significant increase of blood flow(BF) in the CA was observed (p<0.05), however, ITO was not prolonged(169.3±40.9 min). Furthermore, PA was not inhibited by ticlopidine, indicating the ineffectiveness of ticlopidine as an anti-platelet agent in this species. Thus, BF might not be a critical factor for thrombus formation in this model. These results suggest that cilostazol might be an effective agent on the prevention of TIA and stroke in clinical use.