Roles of p53 Codon 72 and miR-502-binding Site in the 3’-UTR of SET8 SNPs in Urinary Bladder Cancer Predisposition in Turkish Population

A case-control study was conducted to elucidate the possible roles of two SNPs (TP53 codon 72 and SET8 miR-502) that may affect each other in the same signaling pathway in bladder cancer susceptibility. Genotype distributions of 180 bladder cancer patients in comparison with 203 cancer-free controls...

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Bibliographic Details
Published inInternational journal of human genetics Vol. 19; no. 3; p. 138
Main Author Yegin, Z.
Format Journal Article
LanguageEnglish
Published Delhi Kamla-Raj Enterprises 01.09.2019
Subjects
3' Untranslated regions
Binding sites
Bladder
Bladder cancer
Cancer
Genotypes
Health risk assessment
p53 Protein
Polymerase chain reaction
Population studies
Researchers
Restriction fragment length polymorphism
Signal transduction
Urinary bladder
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Summary:A case-control study was conducted to elucidate the possible roles of two SNPs (TP53 codon 72 and SET8 miR-502) that may affect each other in the same signaling pathway in bladder cancer susceptibility. Genotype distributions of 180 bladder cancer patients in comparison with 203 cancer-free controls were tested using PCR-RFLP method. For TP53, the researchers observed some protective effect of CC (Pro/Pro) genotype when compared with the heterozygous form (CG). For SET8 miR502, the researchers found no significant association in terms of variant alleles. These data suggest the association of TP53 codon 72 SNP, but not SET8 miR-502 with bladder cancer susceptibility in Turkish population. Further studies with larger sample sizes and different ethnicities are desirable to validate the researchers' findings.
ISSN:0972-3757
2456-6330
DOI:10.31901/24566330.2019/19.03.735