Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism

• Published in: Human genetics Vol. 105; no. 6; pp. 564 - 566
• Main Authors: TACHEZY, R, MIKYSKOVA, I, SALAKOVA, M, VAN RANST, M
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.12.1999; Berlin; New York, NY
• Subjects: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine - genetics; Biological and medical sciences; Blood Donors; Codon; Czech Republic; DNA Mutational Analysis; Female; Female genital diseases; Genotype; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Middle Aged; Papillomaviridae; Papillomavirus Infections - complications; Polymerase Chain Reaction; Polymorphism, Genetic; Proline - genetics; Tumor Suppressor Protein p53 - genetics; Tumor Virus Infections - complications; Tumors; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - virology; Czech Republic; Human; p53 Protein; Papovaviridae; Uterine cervix; Female genital diseases; Papillomavirus; Virus; Case study; Human papillomavirus; Tumor; Uterine cervix diseases; Tumor suppressor gene; Polymorphism
• ISSN: 0340-6717; 1432-1203
• DOI: 10.1007/s004390051146

High-risk mucosal human papillomaviruses encode an E6 oncoprotein, which binds the cellular p53 tumor suppressor protein, thereby marking it for degradation through the ubiquitin-mediated pathway. A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline. Recently reported data suggested an increased susceptibility to E6/ubiquitin-mediated degradation of the Arg72-p53 isoform and an over-representation of the homozygous Arg72-p53 genotype in cervical cancer patients. We have analyzed this polymorphism in a larger series of patients with cervical cancer and in controls in the Czech Republic. We found no statistically significant differences between the codon-72 p53 genotypes of cervical cancer patients and the control women. Based on these results, it is unlikely that Arg72-p53 is associated with an increased risk for human papillomavirus-associated cervical tumor development in Czech women.