Genetic polymorphism and cancer risk

Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1...

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Bibliographic Details
Published inCurrent oncology reports Vol. 2; no. 3; pp. 251 - 256
Main Author Clapper, M L
Format Journal Article
LanguageEnglish
Published United States 01.05.2000
Subjects
Female
Genetic Predisposition to Disease - epidemiology
Genetic Testing
Humans
Male
Neoplasms - epidemiology
Neoplasms - genetics
Polymorphism, Genetic
Risk Assessment
Risk Factors
Sensitivity and Specificity
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Summary:Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1A1, CYP2D6, and CYP2E1), N-acetyltransferase (NAT1 and NAT2), glutathione S-transferase (GSTM1, GSTT1, and GSTP1), microsomal epoxide hydrolase, and NAD(P)H:quinone oxidoreductase. Our understanding of the genetic basis of cancer risk has been enhanced most recently by establishment of genotype-phenotype correlations in humans and identification of numerous diverse factors, both genetic and environmental, that can modify risk.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-000-0075-z