A novel use of Boc-Oxyma as reagent for tert‑butoxycarbonylation of amines and amino acid esters

A facile and suitable approach has been improved to protect different amines including sterically hindered amino acid esters using Boc-Oxyma, as their carbamates in the presence of triethylamine as a base catalyst in neat or solvent medium at room temperature. A significant advantage of this protoco...

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Bibliographic Details
Published inChemical Data Collections Vol. 30; p. 100592
Main Authors Robert, Alice R., Kumar, Ganta Ravi, Kumar, Thoota Sandeep, Maddila, Suresh, Jonnalagadda, Sreekantha B.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2020
Subjects
Amines
Amino acid esters
Boc-Oxyma
Protecting groups
Tert-butoxycarbonylation
Amines
Tert-butoxycarbonylation
Amino acid esters
Protecting groups
Boc-Oxyma
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Summary:A facile and suitable approach has been improved to protect different amines including sterically hindered amino acid esters using Boc-Oxyma, as their carbamates in the presence of triethylamine as a base catalyst in neat or solvent medium at room temperature. A significant advantage of this protocol is easy handling, short reaction times, simple workup process, TEA as solvent plus catalyst under mild conditions, avoid column chromatography for purification technique and excellent product yields.
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2020.100592