Investigation on Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from quadridentate salen-type Schiff base: Structural characterization, DNA interactions, antioxidant proficiency and biological evaluation

• Published in: Chemical Data Collections Vol. 28; p. 100434
• Main Authors: Ramesh, Gali, Daravath, Sreenu, Swathi, M, Sumalatha, V., Shiva Shankar, Dasari, Shivaraj
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2020
• Subjects: Biocidal activity; DNA interaction; Metal complex; Radical scavenging; Metal complex; Biocidal activity; DNA interaction; Radical scavenging
• ISSN: 2405-8300; 2405-8300
• DOI: 10.1016/j.cdc.2020.100434

•A new quadridentate salen-type Schiff base and its binary Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized.•The binding constant values are observed against CT-DNA.•Accomplished antimicrobial and antioxidant proficiency of compounds are observed.•A cleavage study of synthesized compounds indicates supercoiled pBR322 DNA cleaves through oxidative and photolytic type. Four mononuclear metal chelated complexes, [Co(L)] (1), [Ni(L)] (2), [Cu(L)] (3) and [Zn(L)] (4), were designed and synthesized from a novel quadridentate salen-type Schiff base ligand (H2L) derived from 2-hydroxy napthaldehyde and 4-fluoro-1,2-phenylenediamine. The chemical structures of synthesized compounds were fully characterized by various techniques. Spectral and analytical investigations clearly suggested that a square planar geometry around metal centre. The thermal analysis (TGA) of these complexes indicated greater thermal stability and various steps involved in thermal decomposition of metal complexes. The binding ability between the metal complexes and CT-DNA was investigated by UV-Vis, fluorescence spectroscopy and viscometric experiments which revealed an intercalation binding mode of binding. The cleavage property of metal complexes against pBR322 DNA has been explored. The antioxidant activity of M(II) complexes against active free radicals was determined by DPPH free radical scavenging experiment. Furthermore all compounds were screened against antimicrobial activity. [Display omitted]