Hepatotoxicity induced by subacute exposure of Mancozeb and Arsenic in Wistar rats: Mitigating effect of quercetin and catechin
Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As+3) in the groundwater is likely to cause toxicosis in humans and animals. Therefore, the present study aimed to determine the hepatotoxic effect of MZ and As+3 interaction in Wistar rats and mitigating poten...
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Published in | Journal of Trace Elements and Minerals (Online) Vol. 10; p. 100199 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.12.2024
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Abstract | Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As+3) in the groundwater is likely to cause toxicosis in humans and animals. Therefore, the present study aimed to determine the hepatotoxic effect of MZ and As+3 interaction in Wistar rats and mitigating potential of quercetin and catechin on such toxicity.
Sixty adult rats were randomly divided into 10 groups of 6 animals each. Group I served as control and group II was exposed to MZ (800 mg kg-1, PO). Groups III, IV, and V were provided drinking water containing As+3 at the rate of 10, 50 and 100 µg L-1, respectively. Groups VI, VII, and VIII were given drinking water containing As+3 at 10, 50 and 100 µg L-1, respectively, along with MZ. Groups IX and X received drinking water contaminated with 100 µg L-1, As+3 and MZ along with quercetin or catechin (50 mg kg-1 each), respectively.
Significant (p <0.05) alterations in hepatic biomarkers in blood, liver antioxidant status and hepatic histoarchitecture were observed in animals treated with individual toxicants in a dose-dependent manner, however, such toxicity-induced changes were more severe in co-exposed rats. The administration of quercetin or catechin significantly mitigated the dual toxicant administration-driven changes in biochemical markers of hepatic damage, hepatic antioxidant profile and liver histomorphology.
Both quercetin and catechin proved beneficial in reducing toxicant-induced oxidation-mediated hepatic damage as demonstrated by alleviation in altered levels of determinants of hepatic biochemical and oxidative stress parameters in addition to restoration of toxicant-induced histological alterations of hepatic tissue. |
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AbstractList | Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As+3) in the groundwater is likely to cause toxicosis in humans and animals. Therefore, the present study aimed to determine the hepatotoxic effect of MZ and As+3 interaction in Wistar rats and mitigating potential of quercetin and catechin on such toxicity.
Sixty adult rats were randomly divided into 10 groups of 6 animals each. Group I served as control and group II was exposed to MZ (800 mg kg-1, PO). Groups III, IV, and V were provided drinking water containing As+3 at the rate of 10, 50 and 100 µg L-1, respectively. Groups VI, VII, and VIII were given drinking water containing As+3 at 10, 50 and 100 µg L-1, respectively, along with MZ. Groups IX and X received drinking water contaminated with 100 µg L-1, As+3 and MZ along with quercetin or catechin (50 mg kg-1 each), respectively.
Significant (p <0.05) alterations in hepatic biomarkers in blood, liver antioxidant status and hepatic histoarchitecture were observed in animals treated with individual toxicants in a dose-dependent manner, however, such toxicity-induced changes were more severe in co-exposed rats. The administration of quercetin or catechin significantly mitigated the dual toxicant administration-driven changes in biochemical markers of hepatic damage, hepatic antioxidant profile and liver histomorphology.
Both quercetin and catechin proved beneficial in reducing toxicant-induced oxidation-mediated hepatic damage as demonstrated by alleviation in altered levels of determinants of hepatic biochemical and oxidative stress parameters in addition to restoration of toxicant-induced histological alterations of hepatic tissue. Background: Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As+3) in the groundwater is likely to cause toxicosis in humans and animals. Therefore, the present study aimed to determine the hepatotoxic effect of MZ and As+3 interaction in Wistar rats and mitigating potential of quercetin and catechin on such toxicity. Methods: Sixty adult rats were randomly divided into 10 groups of 6 animals each. Group I served as control and group II was exposed to MZ (800 mg kg-1, PO). Groups III, IV, and V were provided drinking water containing As+3 at the rate of 10, 50 and 100 µg L-1, respectively. Groups VI, VII, and VIII were given drinking water containing As+3 at 10, 50 and 100 µg L-1, respectively, along with MZ. Groups IX and X received drinking water contaminated with 100 µg L-1, As+3 and MZ along with quercetin or catechin (50 mg kg-1 each), respectively. Results: Significant (p <0.05) alterations in hepatic biomarkers in blood, liver antioxidant status and hepatic histoarchitecture were observed in animals treated with individual toxicants in a dose-dependent manner, however, such toxicity-induced changes were more severe in co-exposed rats. The administration of quercetin or catechin significantly mitigated the dual toxicant administration-driven changes in biochemical markers of hepatic damage, hepatic antioxidant profile and liver histomorphology. Conclusions: Both quercetin and catechin proved beneficial in reducing toxicant-induced oxidation-mediated hepatic damage as demonstrated by alleviation in altered levels of determinants of hepatic biochemical and oxidative stress parameters in addition to restoration of toxicant-induced histological alterations of hepatic tissue. |
ArticleNumber | 100199 |
Author | Bhat, Zuhaib F. Sharma, Priyanka Sood, Shilpa Verma, Pawan Kumar Yousuf, Rasia Pankaj, Nrip K. |
Author_xml | – sequence: 1 givenname: Rasia surname: Yousuf fullname: Yousuf, Rasia organization: Division of Veterinary Pharmacology and Toxicology, F.V.Sc. & A.H., Jammu, J&K, 181102, India – sequence: 2 givenname: Pawan Kumar surname: Verma fullname: Verma, Pawan Kumar email: drpawankv@yahoo.co.in organization: Division of Veterinary Pharmacology and Toxicology, F.V.Sc. & A.H., Jammu, J&K, 181102, India – sequence: 3 givenname: Priyanka surname: Sharma fullname: Sharma, Priyanka organization: Division of Veterinary Pharmacology and Toxicology, F.V.Sc. & A.H., Jammu, J&K, 181102, India – sequence: 4 givenname: Shilpa orcidid: 0000-0001-7548-1249 surname: Sood fullname: Sood, Shilpa email: shilpasoo@gmail.com organization: Division of Veterinary Pathology, F.V.Sc. & A.H., Jammu, J&K, 181102, India – sequence: 5 givenname: Nrip K. orcidid: 0000-0001-9320-3007 surname: Pankaj fullname: Pankaj, Nrip K. organization: Division of Veterinary Pharmacology and Toxicology, F.V.Sc. & A.H., Jammu, J&K, 181102, India – sequence: 6 givenname: Zuhaib F. surname: Bhat fullname: Bhat, Zuhaib F. email: zuhaibbhat@yahoo.co.in organization: Division of Livestock Products Technology, SKUAST-Jammu, India, 181102 |
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Cites_doi | 10.1093/jn/104.5.580 10.1016/j.lfs.2020.118438 10.1016/j.taap.2005.06.001 10.1016/j.ecoenv.2022.113200 10.1016/j.biopha.2018.03.136 10.1016/S0021-9258(19)41206-4 10.1111/j.1749-6632.2002.tb04928.x 10.1007/s11356-021-15695-4 10.1016/j.ecoenv.2019.109467 10.1016/j.envint.2016.11.006 10.1515/jbcpp-2018-0230 10.1016/j.fct.2013.01.056 10.1177/0748233718778993 10.1038/ki.1996.186 10.1016/j.jhazmat.2020.123160 10.11648/j.ab.20190702.12 10.1155/2024/8815630 10.1007/s11356-020-09569-4 10.1016/j.lfs.2018.08.054 10.1016/j.reprotox.2005.08.004 10.1371/journal.pone.0020635 10.1007/s11033-019-05217-4 10.1016/j.arabjc.2013.04.026 10.3390/molecules27196545 10.1016/j.focha.2023.100380 10.1002/fsn3.3278 10.1016/0378-4274(84)90093-6 10.1016/j.sjbs.2016.11.017 10.3109/0886022X.2015.1103585 10.1007/s10616-017-0138-8 10.1093/toxsci/kfr006 10.1016/j.taap.2005.07.002 10.1016/j.eti.2019.100462 10.4274/jcrpe.1454 10.1111/j.1432-1033.1974.tb03714.x 10.1177/0748233719834150 10.2310/JIM.0b013e31823581dd 10.3109/13880209.2015.1043562 10.1016/j.lfs.2011.12.013 10.1016/0076-6879(94)34094-3 10.1007/s11356-017-0542-9 10.18311/ti/2023/v30i3/32276 |
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Keywords | Mancozeb Catechin Arsenic Oxidative damage Hepatotoxicity Quercetin |
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References | Goswami, Singh, Chakdar, Choudhary (bib0007) 2018; 11 Yousuf, Verma, Sharma, Bhatti, Bhat (bib0058) 2023; 11 Furlong, Richter, Seidel, Motulsky (bib0025) 1988; 43 Hafeman, Sunde, Hoekstra (bib0023) 1974; 104 Cheruku, Ramalingayya, Chamallamudi, Biswas, Nandakumar, Nampoothiri, Gourishetti, Kumar (bib0050) 2018; 70 Yousuf, Verma, Sharma, Sood, Kaddour, Bhat (bib0054) 2023; 5 Mahajan, Verma, Raina, Sood (bib0012) 2018; 34 Marklund, Marklund (bib0021) 1974; 47 Calviello, Piccioni, Boninsegna, Tedesco, Maggiano, Serini, Wolf, Palozza (bib0037) 2006; 211 Re, Pellegrini, Proteggente, Pannala, Yang, Rice-Ewans (bib0019) 1999; 26 Dallagnol, Pezzini, Uribe, Joveleviths (bib0030) 2021; 25 Souza, Basto, Marcela (bib0036) 2018; 209 Eren, Abuhandan, Solmaz, Taskin (bib0043) 2014; 6 Motchnik, Frei, Ames (bib0020) 1994; 23 Cebeci, Alibaz-Oner, Usta, Yurdakul, Erguney (bib0042) 2012; 60 Aziz, Abdel-Wahab, El-Ela, Hassan, El-Nahass, Ibrahim, Khalil (bib0017) 2018; 102 Verma, Raina, Sultana, Singh, Kumar (bib0015) 2016; 38 Akinmoladun, Olaniyan, Famusiwa, Josiah, Olaleye (bib0047) 2020; 31 Sharma, Verma, Sood, Raina, Bhat, Aadil (bib0056) 2024 Witko-Sarsat, Friedlander, Capeillère-Blandin (bib0027) 1996; 49 Santra, Maiti, Das, Charkaborty, Mazumder (bib0031) 2000; 38 Renu, Saravanan, Elangovan, Ramesh, Annamalai, Namachivayam, Abel, Madhyastha, Madhyastha, Maruyama, Balachandar, Gopalakrishnan (bib0035) 2020; 260 Yousuf, Verma, Sharma, Sood, Pankaj, Agarwal (bib0055) 2023; 30 Yousuf, Verma, Sharma, Sood, Bhat (bib0057) 2023; 3 Axelstad, Boberg, Nellemann, Kiersgaard, Jacobsen, Christiansen, Hougaard, Hass (bib0006) 2011; 120 Owumi, Nwozo, Najophe (bib0046) 2019; 3 Hu, Li, Lou, Wu, Wang, Lu, Wang, Pi, Xu (bib0039) 2020; 10 Corsini, Viviani, Birindelli, Gilardi, Torri, Codecà, Colosio (bib0005) 2006; 212 Carlberg, Mannervik (bib0024) 1975; 250 Edward, Ferry, Temple, Kamrin (bib0016) 1997 Rossi, Buccione, Baldassarre, Macchiarelli, Palmerini, Cecconi (bib0010) 2006; 21 Runkle, Flocks, Economos, Dunlop (bib0009) 2017; 99 Bharrhan, Koul, Chopra, Rishi (bib0018) 2011; 6 Dkhil, Abdel Moneim, Bauomy, Khalil, Al-Shaebi, Al-Quraishy (bib0033) 2020; 47 Kanchi, Singh, Bisetty (bib0002) 2013; 7 Preeti, Aksha, Nakuleshwar, Nidhi, Suresh (bib0001) 2015; 6 Flora, Mittal, Mehta (bib0011) 2008; 128 Klibet, Boumendjel, Khiari, El Feki, Abdennour, Messarah (bib0014) 2016; 54 Sakr (bib0051) 2007; 1 Simakani, Abolhasani, Hoseini (bib0032) 2018; 6 Yahia, El-Amir, Rushdi (bib0029) 2019; 35 Bahrami, Sathyapalan, Moallem, Sahebkar (bib0041) 2020; 400 Afolabi, Ugbaja, Arinola, Olorunnisola, Adeleke (bib0049) 2016; 9 Mosolin, Mehana, Oda, Elblehi, El-Karim (bib0053) 2022; 73 Ola, Ahmed, Shams, Al-Rejaie (bib0060) 2017; 24 Ishaq, Gulzar, Hassan, Kamran, Riaz, Parveen, Chattha, Walayat, Fatima, Afzal, Fahad (bib0034) 2021; 28 Saber, Abo-Elmaaty, Abdel-Ghany (bib0038) 2019; 183 Srivastava, Ali, Singh, Bhui, Tyagi, Al-Khedhairy, Srivastava, Musarrat, Shukla (bib0008) 2012; 90 Maji, Biswas, Sarkar, Patra, Bandyopadhyay, Sarkar, Chattopadhyay, Mandal (bib0040) 2020; 27 R.A.B. Drury, WEA, Carleton's Histological Technique. Open Library. (1980). Gullino, Tinivella, Garibaldi A, Kemmitt, Bacci, Sheppard (bib0003) 2010; 94 Shafiq-Ur-Rehman (bib0026) 1984; 21 Aebi (bib0022) 1983 Uzun, Kalender (bib0052) 2013; 55 Belpoggi, Soffritti, Guarino, Lambertini, Cevolani, Maltoni (bib0004) 2002; 982 Hashem, Mohamed, Attia (bib0045) 2018; 25 Arslan, Seven, Mutlu, Arkali, Birben, Tatli (bib0048) 2022; 231 Kayode, Abimbola, Adesola, Teslim, Dorcas (bib0044) 2019; 7 Sodhi, Kumar, Agrawal, Singh (bib0013) 2019; 16 Qi, Qi, Xiong, Long (bib0059) 2022; 27 Bharrhan (10.1016/j.jtemin.2024.100199_bib0018) 2011; 6 Yahia (10.1016/j.jtemin.2024.100199_bib0029) 2019; 35 Preeti (10.1016/j.jtemin.2024.100199_bib0001) 2015; 6 Runkle (10.1016/j.jtemin.2024.100199_bib0009) 2017; 99 Yousuf (10.1016/j.jtemin.2024.100199_bib0058) 2023; 11 Gullino (10.1016/j.jtemin.2024.100199_bib0003) 2010; 94 Corsini (10.1016/j.jtemin.2024.100199_bib0005) 2006; 212 Ishaq (10.1016/j.jtemin.2024.100199_bib0034) 2021; 28 Bahrami (10.1016/j.jtemin.2024.100199_bib0041) 2020; 400 Simakani (10.1016/j.jtemin.2024.100199_bib0032) 2018; 6 Flora (10.1016/j.jtemin.2024.100199_bib0011) 2008; 128 Cheruku (10.1016/j.jtemin.2024.100199_bib0050) 2018; 70 Akinmoladun (10.1016/j.jtemin.2024.100199_bib0047) 2020; 31 Dkhil (10.1016/j.jtemin.2024.100199_bib0033) 2020; 47 Aziz (10.1016/j.jtemin.2024.100199_bib0017) 2018; 102 Kayode (10.1016/j.jtemin.2024.100199_bib0044) 2019; 7 Hafeman (10.1016/j.jtemin.2024.100199_bib0023) 1974; 104 Qi (10.1016/j.jtemin.2024.100199_bib0059) 2022; 27 Kanchi (10.1016/j.jtemin.2024.100199_bib0002) 2013; 7 Goswami (10.1016/j.jtemin.2024.100199_bib0007) 2018; 11 Eren (10.1016/j.jtemin.2024.100199_bib0043) 2014; 6 Sodhi (10.1016/j.jtemin.2024.100199_bib0013) 2019; 16 Shafiq-Ur-Rehman (10.1016/j.jtemin.2024.100199_bib0026) 1984; 21 Santra (10.1016/j.jtemin.2024.100199_bib0031) 2000; 38 Yousuf (10.1016/j.jtemin.2024.100199_bib0054) 2023; 5 Axelstad (10.1016/j.jtemin.2024.100199_bib0006) 2011; 120 Owumi (10.1016/j.jtemin.2024.100199_bib0046) 2019; 3 Marklund (10.1016/j.jtemin.2024.100199_bib0021) 1974; 47 Witko-Sarsat (10.1016/j.jtemin.2024.100199_bib0027) 1996; 49 Ola (10.1016/j.jtemin.2024.100199_bib0060) 2017; 24 Mahajan (10.1016/j.jtemin.2024.100199_bib0012) 2018; 34 10.1016/j.jtemin.2024.100199_bib0028 Carlberg (10.1016/j.jtemin.2024.100199_bib0024) 1975; 250 Hashem (10.1016/j.jtemin.2024.100199_bib0045) 2018; 25 Edward (10.1016/j.jtemin.2024.100199_bib0016) 1997 Hu (10.1016/j.jtemin.2024.100199_bib0039) 2020; 10 Sharma (10.1016/j.jtemin.2024.100199_bib0056) 2024 Rossi (10.1016/j.jtemin.2024.100199_bib0010) 2006; 21 Mosolin (10.1016/j.jtemin.2024.100199_bib0053) 2022; 73 Yousuf (10.1016/j.jtemin.2024.100199_bib0055) 2023; 30 Verma (10.1016/j.jtemin.2024.100199_bib0015) 2016; 38 Motchnik (10.1016/j.jtemin.2024.100199_bib0020) 1994; 23 Srivastava (10.1016/j.jtemin.2024.100199_bib0008) 2012; 90 Calviello (10.1016/j.jtemin.2024.100199_bib0037) 2006; 211 Re (10.1016/j.jtemin.2024.100199_bib0019) 1999; 26 Dallagnol (10.1016/j.jtemin.2024.100199_bib0030) 2021; 25 Saber (10.1016/j.jtemin.2024.100199_bib0038) 2019; 183 Maji (10.1016/j.jtemin.2024.100199_bib0040) 2020; 27 Sakr (10.1016/j.jtemin.2024.100199_bib0051) 2007; 1 Aebi (10.1016/j.jtemin.2024.100199_bib0022) 1983 Furlong (10.1016/j.jtemin.2024.100199_bib0025) 1988; 43 Afolabi (10.1016/j.jtemin.2024.100199_bib0049) 2016; 9 Klibet (10.1016/j.jtemin.2024.100199_bib0014) 2016; 54 Renu (10.1016/j.jtemin.2024.100199_bib0035) 2020; 260 Arslan (10.1016/j.jtemin.2024.100199_bib0048) 2022; 231 Cebeci (10.1016/j.jtemin.2024.100199_bib0042) 2012; 60 Uzun (10.1016/j.jtemin.2024.100199_bib0052) 2013; 55 Belpoggi (10.1016/j.jtemin.2024.100199_bib0004) 2002; 982 Souza (10.1016/j.jtemin.2024.100199_bib0036) 2018; 209 Yousuf (10.1016/j.jtemin.2024.100199_bib0057) 2023; 3 |
References_xml | – volume: 250 start-page: 5475 year: 1975 end-page: 5480 ident: bib0024 article-title: Purification and characterization of the flavoenzyme glutathione reductase from rat liver publication-title: J. Biol. Chem. contributor: fullname: Mannervik – volume: 31 year: 2020 ident: bib0047 article-title: Ameliorative effect of quercetin, catechin, and taxifolin on rotenone-induced testicular and splenic weight gain and oxidative stress in rats publication-title: J. Basic Clin. Physiol. Pharmacol. contributor: fullname: Olaleye – volume: 94 start-page: 1077 year: 2010 end-page: 1087 ident: bib0003 article-title: Mancozeb past, present and future publication-title: The American Phytopathological Society contributor: fullname: Sheppard – volume: 90 start-page: 815 year: 2012 end-page: 824 ident: bib0008 article-title: Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes publication-title: Life Sci. contributor: fullname: Shukla – volume: 9 year: 2016 ident: bib0049 article-title: Catechin protects against dyslipidemia and nephro-hepatotoxicity induced in rats exposed to arsenic publication-title: Jordan J. Biol. Sci. contributor: fullname: Adeleke – volume: 209 start-page: 472 year: 2018 end-page: 480 ident: bib0036 article-title: Arsenic aggravates oxidative stress causing hepatic alterations and inflammation in diabetes rats publication-title: Life Sci. contributor: fullname: Marcela – volume: 982 start-page: 123 year: 2002 end-page: 136 ident: bib0004 article-title: Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Maltoni – volume: 7 start-page: 11 year: 2013 end-page: 25 ident: bib0002 article-title: Dithiocarbamates as hazardous remediation agent: A critical review on progress in environmental chemistry for inorganic species studies of 20 publication-title: Arabian J. Chem. contributor: fullname: Bisetty – volume: 23 start-page: 269 year: 1994 end-page: 279 ident: bib0020 article-title: Measurement of antioxidants in human blood plasma publication-title: Methods Enzymol. contributor: fullname: Ames – volume: 25 start-page: 4113 year: 2021 end-page: 4120 ident: bib0030 article-title: Systemic effects of the pesticide mancozeb- A literature review publication-title: Eur. Rev. Med. Pharm. Sci. contributor: fullname: Joveleviths – volume: 400 year: 2020 ident: bib0041 article-title: Counteracting arsenic toxicity: Curcumin to the rescue publication-title: J. Hazard. Mater. contributor: fullname: Sahebkar – volume: 25 start-page: 1270 year: 2018 end-page: 1282 ident: bib0045 article-title: Assessment of protective potential of Nigella sativa oil against carbendazim-and/or mancozeb-induced hematotoxicity, hepatotoxicity, and genotoxicity publication-title: Environ. Sci. Pollut. Res. contributor: fullname: Attia – volume: 6 start-page: 163 year: 2014 end-page: 168 ident: bib0043 article-title: Serum paraoxonase/arylesterase activity and oxidative stress status in children with metabolic syndrome publication-title: J. Clin. Res. Paed. Endocrinol. contributor: fullname: Taskin – volume: 70 start-page: 245 year: 2018 end-page: 259 ident: bib0050 article-title: Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in publication-title: Cytotechnol contributor: fullname: Kumar – volume: 49 start-page: 1304 year: 1996 end-page: 1313 ident: bib0027 article-title: Advanced oxidation protein products as a novel marker of oxidative stress in uraemia publication-title: Kidney Int. contributor: fullname: Capeillère-Blandin – volume: 99 start-page: 29 year: 2017 end-page: 42 ident: bib0009 article-title: A systematic review of Mancozeb as a reproductive and developmental hazard publication-title: Environ. Int. contributor: fullname: Dunlop – volume: 30 start-page: 255 year: 2023 end-page: 267 ident: bib0055 article-title: Testicular Toxicity following subacute exposure of arsenic and mancozeb alone and in combination: Ameliorative efficacy of quercetin and catechin publication-title: Toxicol. Int. contributor: fullname: Agarwal – volume: 35 start-page: 265 year: 2019 end-page: 276 ident: bib0029 article-title: Mancozeb fungicide-induced genotoxic effects, metabolic alterations, and histological changes in the colon and liver of Sprague Dawley rats publication-title: Toxicol. Ind. Health contributor: fullname: Rushdi – volume: 6 start-page: 157 year: 2018 end-page: 161 ident: bib0032 article-title: Determination of mancozeb toxicity and biochemical effects in common carp ( publication-title: Int. J. Aqua. Biol. contributor: fullname: Hoseini – volume: 6 start-page: e20635 year: 2011 ident: bib0018 article-title: Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model publication-title: PLoS One contributor: fullname: Rishi – start-page: 91 year: 1997 end-page: 132 ident: bib0016 article-title: Thiodithiocarbamates publication-title: Pesticide Profiles: Toxicity, Environmental Impact, and Fate contributor: fullname: Kamrin – volume: 260 year: 2020 ident: bib0035 article-title: An appraisal on molecular and biochemical signaling cascades during arsenic-induced hepatotoxicity publication-title: Life Sci. contributor: fullname: Gopalakrishnan – volume: 1 start-page: 650 year: 2007 end-page: 656 ident: bib0051 article-title: Ameliorative effect of ginger ( publication-title: Aust. J. Basic Appl. Sci. contributor: fullname: Sakr – volume: 38 start-page: 395 year: 2000 end-page: 405 ident: bib0031 article-title: Hepatic damage caused by chronic arsenic toxicity in experimental animals publication-title: Clin. Toxicol. contributor: fullname: Mazumder – volume: 212 start-page: 89 year: 2006 end-page: 98 ident: bib0005 article-title: Molecular mechanisms underlying mancozeb-induced inhibition of TNF-alpha production publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Colosio – volume: 211 start-page: 87 year: 2006 end-page: 96 ident: bib0037 article-title: DNA damage and apoptosis induction by the pesticide mancozeb in rat cells: Involvement of the oxidative mechanism publication-title: Toxicol. Appl. Pharm. contributor: fullname: Palozza – volume: 120 start-page: 439 year: 2011 end-page: 446 ident: bib0006 article-title: Exposure to the widely used fungicide mancozeb causes thyroid harmone disruption in rat dams but no behavioral effects in the offspring publication-title: Toxicol. Sci. contributor: fullname: Hass – volume: 38 start-page: 142 year: 2016 end-page: 150 ident: bib0015 article-title: Total antioxidant and oxidant status of plasma and renal tissue of cisplatin-induced nephrotoxic rats: Protection by floral extracts of publication-title: Renal Failure contributor: fullname: Kumar – volume: 11 start-page: 1011 year: 2018 end-page: 1019 ident: bib0007 article-title: Harmful effects of fungicides-current status publication-title: IJAEB contributor: fullname: Choudhary – volume: 3 year: 2023 ident: bib0057 article-title: Quercetin and catechin supplementation provide protection against arsenic and mancozeb-induced toxicity in Wistar rats publication-title: Food Chem. Advances contributor: fullname: Bhat – volume: 128 start-page: 501 year: 2008 ident: bib0011 article-title: Heavy metal induced oxidative stress & its possible reversal by chelation therapy publication-title: Indian J. Med. Res. contributor: fullname: Mehta – volume: 47 start-page: 1161 year: 2020 end-page: 1171 ident: bib0033 article-title: Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis publication-title: Mol. Biol. Rep. contributor: fullname: Al-Quraishy – volume: 3 year: 2019 ident: bib0046 article-title: Quercetin abates induction of hepatic and renal oxidative damage, inflammation, and apoptosis in carbendazim-treated rats publication-title: Toxicol. Res. Appl. contributor: fullname: Najophe – volume: 43 start-page: 230 year: 1988 end-page: 238 ident: bib0025 article-title: Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon publication-title: Am. J. Human Genetics contributor: fullname: Motulsky – volume: 104 start-page: 580 year: 1974 end-page: 587 ident: bib0023 article-title: Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat publication-title: J. Nutr. contributor: fullname: Hoekstra – volume: 7 start-page: 51 year: 2019 ident: bib0044 article-title: Catechin attenuates the effect of combined arsenic and deltamethrin toxicity by abrogation of oxidative stress and inflammation in Wistar rats publication-title: Adv. Biochem. contributor: fullname: Dorcas – volume: 27 start-page: 36744 year: 2020 end-page: 36753 ident: bib0040 article-title: Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep publication-title: Environ. Sci. Pollut. Res. contributor: fullname: Mandal – year: 2024 ident: bib0056 article-title: Ameliorative Potential of Ginger ( publication-title: J. Food Biochem. contributor: fullname: Aadil – volume: 6 start-page: 348 year: 2015 ident: bib0001 article-title: A Review on Toxicological Effects of Fungicides publication-title: Res. J. Pharm. Biol. Chem. Sci. contributor: fullname: Suresh – start-page: 673 year: 1983 ident: bib0022 article-title: Catalase publication-title: Methods of enzymatic analysis contributor: fullname: Aebi – volume: 27 start-page: 6545 year: 2022 ident: bib0059 article-title: Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy publication-title: Molecules contributor: fullname: Long – volume: 10 start-page: 240 year: 2020 ident: bib0039 article-title: The role of reactive oxygen species in arsenic toxicity publication-title: Biomol. contributor: fullname: Xu – volume: 21 start-page: 333 year: 1984 end-page: 337 ident: bib0026 article-title: Lead-induced regional lipid peroxidation in brain publication-title: Toxicol. Lett. contributor: fullname: Shafiq-Ur-Rehman – volume: 21 start-page: 216 year: 2006 end-page: 219 ident: bib0010 article-title: Mancozeb exposure publication-title: Reproductive Toxicol. contributor: fullname: Cecconi – volume: 26 start-page: 1231 year: 1999 end-page: 1237 ident: bib0019 article-title: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Rad publication-title: Biol. Med. contributor: fullname: Rice-Ewans – volume: 183 year: 2019 ident: bib0038 article-title: Curcumin mitigates mancozeb-induced hepatotoxicity and genotoxicity in rats publication-title: Ecotoxicol. Environ. Saf. contributor: fullname: Abdel-Ghany – volume: 16 year: 2019 ident: bib0013 article-title: Perspectives on arsenic toxicity, carcinogenicity and its systemic remediation strategies publication-title: Environ. Technol. Innov. contributor: fullname: Singh – volume: 55 start-page: 549 year: 2013 end-page: 556 ident: bib0052 article-title: Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin publication-title: Food Chem. Toxicol. contributor: fullname: Kalender – volume: 54 start-page: 354 year: 2016 end-page: 363 ident: bib0014 article-title: Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation by publication-title: Pharmaceut. Biol. contributor: fullname: Messarah – volume: 102 start-page: 855 year: 2018 end-page: 864 ident: bib0017 article-title: Dose-dependent ameliorative effects of quercetin and l-Carnitine against atrazine-induced reproductive toxicity in adult male Albino rats publication-title: Biomed. Pharmacother. contributor: fullname: Khalil – volume: 28 start-page: 66313 year: 2021 end-page: 66326 ident: bib0034 article-title: Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats publication-title: Environ. Sci. Pollut. Res. contributor: fullname: Fahad – volume: 24 start-page: 1186 year: 2017 end-page: 1194 ident: bib0060 article-title: Neuroprotective effects of quercetin in diabetic rat retina publication-title: Saudi J. Biol. Sci. contributor: fullname: Al-Rejaie – volume: 60 start-page: 23 year: 2012 end-page: 28 ident: bib0042 article-title: Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism publication-title: J. Invest. Med. contributor: fullname: Erguney – volume: 34 start-page: 726 year: 2018 end-page: 735 ident: bib0012 article-title: Toxic effects of imidacloprid combined with arsenic: Oxidative stress in rat liver publication-title: Toxicol. Ind. Health contributor: fullname: Sood – volume: 11 start-page: 2964 year: 2023 end-page: 2973 ident: bib0058 article-title: Neuroprotective effect of quercetin and publication-title: Food Sci. Nutri. contributor: fullname: Bhat – volume: 73 year: 2022 ident: bib0053 article-title: Ameliorative effect of green tea and quercetin against cadmium-induced hepato-renal toxicity in rats publication-title: Alexandria J. Vet. Sci. contributor: fullname: El-Karim – volume: 5 year: 2023 ident: bib0054 article-title: Ameliorative potential of quercetin and catechin against sodium arsenite and mancozeb-induced oxidative renal damage in Wistar rats publication-title: J. Trace Ele. Minerals contributor: fullname: Bhat – volume: 231 year: 2022 ident: bib0048 article-title: Potential ameliorative effect of dietary quercetin against lead-induced oxidative stress, biochemical changes, and apoptosis in laying Japanese quails publication-title: Ecotoxicol. Environ. Saf. contributor: fullname: Tatli – volume: 47 start-page: 469 year: 1974 end-page: 474 ident: bib0021 article-title: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase publication-title: Eur. J. Biochem. contributor: fullname: Marklund – volume: 104 start-page: 580 year: 1974 ident: 10.1016/j.jtemin.2024.100199_bib0023 article-title: Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat publication-title: J. Nutr. doi: 10.1093/jn/104.5.580 contributor: fullname: Hafeman – volume: 10 start-page: 240 year: 2020 ident: 10.1016/j.jtemin.2024.100199_bib0039 article-title: The role of reactive oxygen species in arsenic toxicity publication-title: Biomol. contributor: fullname: Hu – volume: 260 year: 2020 ident: 10.1016/j.jtemin.2024.100199_bib0035 article-title: An appraisal on molecular and biochemical signaling cascades during arsenic-induced hepatotoxicity publication-title: Life Sci. doi: 10.1016/j.lfs.2020.118438 contributor: fullname: Renu – volume: 211 start-page: 87 year: 2006 ident: 10.1016/j.jtemin.2024.100199_bib0037 article-title: DNA damage and apoptosis induction by the pesticide mancozeb in rat cells: Involvement of the oxidative mechanism publication-title: Toxicol. Appl. Pharm. doi: 10.1016/j.taap.2005.06.001 contributor: fullname: Calviello – volume: 231 year: 2022 ident: 10.1016/j.jtemin.2024.100199_bib0048 article-title: Potential ameliorative effect of dietary quercetin against lead-induced oxidative stress, biochemical changes, and apoptosis in laying Japanese quails publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2022.113200 contributor: fullname: Arslan – volume: 11 start-page: 1011 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0007 article-title: Harmful effects of fungicides-current status publication-title: IJAEB contributor: fullname: Goswami – volume: 128 start-page: 501 year: 2008 ident: 10.1016/j.jtemin.2024.100199_bib0011 article-title: Heavy metal induced oxidative stress & its possible reversal by chelation therapy publication-title: Indian J. Med. Res. contributor: fullname: Flora – volume: 102 start-page: 855 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0017 article-title: Dose-dependent ameliorative effects of quercetin and l-Carnitine against atrazine-induced reproductive toxicity in adult male Albino rats publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2018.03.136 contributor: fullname: Aziz – volume: 9 issue: 3 year: 2016 ident: 10.1016/j.jtemin.2024.100199_bib0049 article-title: Catechin protects against dyslipidemia and nephro-hepatotoxicity induced in rats exposed to arsenic publication-title: Jordan J. Biol. Sci. contributor: fullname: Afolabi – volume: 250 start-page: 5475 year: 1975 ident: 10.1016/j.jtemin.2024.100199_bib0024 article-title: Purification and characterization of the flavoenzyme glutathione reductase from rat liver publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)41206-4 contributor: fullname: Carlberg – volume: 43 start-page: 230 year: 1988 ident: 10.1016/j.jtemin.2024.100199_bib0025 article-title: Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon publication-title: Am. J. Human Genetics contributor: fullname: Furlong – volume: 982 start-page: 123 year: 2002 ident: 10.1016/j.jtemin.2024.100199_bib0004 article-title: Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2002.tb04928.x contributor: fullname: Belpoggi – volume: 28 start-page: 66313 year: 2021 ident: 10.1016/j.jtemin.2024.100199_bib0034 article-title: Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-021-15695-4 contributor: fullname: Ishaq – volume: 6 start-page: 157 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0032 article-title: Determination of mancozeb toxicity and biochemical effects in common carp (Cyprinus carpio) publication-title: Int. J. Aqua. Biol. contributor: fullname: Simakani – volume: 183 year: 2019 ident: 10.1016/j.jtemin.2024.100199_bib0038 article-title: Curcumin mitigates mancozeb-induced hepatotoxicity and genotoxicity in rats publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2019.109467 contributor: fullname: Saber – volume: 99 start-page: 29 year: 2017 ident: 10.1016/j.jtemin.2024.100199_bib0009 article-title: A systematic review of Mancozeb as a reproductive and developmental hazard publication-title: Environ. Int. doi: 10.1016/j.envint.2016.11.006 contributor: fullname: Runkle – volume: 31 year: 2020 ident: 10.1016/j.jtemin.2024.100199_bib0047 article-title: Ameliorative effect of quercetin, catechin, and taxifolin on rotenone-induced testicular and splenic weight gain and oxidative stress in rats publication-title: J. Basic Clin. Physiol. Pharmacol. doi: 10.1515/jbcpp-2018-0230 contributor: fullname: Akinmoladun – volume: 55 start-page: 549 year: 2013 ident: 10.1016/j.jtemin.2024.100199_bib0052 article-title: Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2013.01.056 contributor: fullname: Uzun – volume: 34 start-page: 726 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0012 article-title: Toxic effects of imidacloprid combined with arsenic: Oxidative stress in rat liver publication-title: Toxicol. Ind. Health doi: 10.1177/0748233718778993 contributor: fullname: Mahajan – volume: 26 start-page: 1231 year: 1999 ident: 10.1016/j.jtemin.2024.100199_bib0019 article-title: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Rad publication-title: Biol. Med. contributor: fullname: Re – volume: 49 start-page: 1304 year: 1996 ident: 10.1016/j.jtemin.2024.100199_bib0027 article-title: Advanced oxidation protein products as a novel marker of oxidative stress in uraemia publication-title: Kidney Int. doi: 10.1038/ki.1996.186 contributor: fullname: Witko-Sarsat – volume: 400 year: 2020 ident: 10.1016/j.jtemin.2024.100199_bib0041 article-title: Counteracting arsenic toxicity: Curcumin to the rescue publication-title: J. Hazard. Mater. doi: 10.1016/j.jhazmat.2020.123160 contributor: fullname: Bahrami – volume: 7 start-page: 51 year: 2019 ident: 10.1016/j.jtemin.2024.100199_bib0044 article-title: Catechin attenuates the effect of combined arsenic and deltamethrin toxicity by abrogation of oxidative stress and inflammation in Wistar rats publication-title: Adv. Biochem. doi: 10.11648/j.ab.20190702.12 contributor: fullname: Kayode – year: 2024 ident: 10.1016/j.jtemin.2024.100199_bib0056 article-title: Ameliorative Potential of Ginger (Zingiber officinale) following Repeated co-exposure with Fluoride and Dimethoate in Blood and Brain of Wistar Rats publication-title: J. Food Biochem. doi: 10.1155/2024/8815630 contributor: fullname: Sharma – volume: 27 start-page: 36744 year: 2020 ident: 10.1016/j.jtemin.2024.100199_bib0040 article-title: Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-020-09569-4 contributor: fullname: Maji – volume: 209 start-page: 472 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0036 article-title: Arsenic aggravates oxidative stress causing hepatic alterations and inflammation in diabetes rats publication-title: Life Sci. doi: 10.1016/j.lfs.2018.08.054 contributor: fullname: Souza – volume: 21 start-page: 216 year: 2006 ident: 10.1016/j.jtemin.2024.100199_bib0010 article-title: Mancozeb exposure in vivo impairs mouse oocyte fertilizability publication-title: Reproductive Toxicol. doi: 10.1016/j.reprotox.2005.08.004 contributor: fullname: Rossi – volume: 6 start-page: e20635 issue: 6 year: 2011 ident: 10.1016/j.jtemin.2024.100199_bib0018 article-title: Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model publication-title: PLoS One doi: 10.1371/journal.pone.0020635 contributor: fullname: Bharrhan – volume: 47 start-page: 1161 year: 2020 ident: 10.1016/j.jtemin.2024.100199_bib0033 article-title: Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-019-05217-4 contributor: fullname: Dkhil – volume: 7 start-page: 11 year: 2013 ident: 10.1016/j.jtemin.2024.100199_bib0002 article-title: Dithiocarbamates as hazardous remediation agent: A critical review on progress in environmental chemistry for inorganic species studies of 20th century publication-title: Arabian J. Chem. doi: 10.1016/j.arabjc.2013.04.026 contributor: fullname: Kanchi – volume: 73 year: 2022 ident: 10.1016/j.jtemin.2024.100199_bib0053 article-title: Ameliorative effect of green tea and quercetin against cadmium-induced hepato-renal toxicity in rats publication-title: Alexandria J. Vet. Sci. contributor: fullname: Mosolin – volume: 27 start-page: 6545 issue: 19 year: 2022 ident: 10.1016/j.jtemin.2024.100199_bib0059 article-title: Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy publication-title: Molecules doi: 10.3390/molecules27196545 contributor: fullname: Qi – volume: 25 start-page: 4113 year: 2021 ident: 10.1016/j.jtemin.2024.100199_bib0030 article-title: Systemic effects of the pesticide mancozeb- A literature review publication-title: Eur. Rev. Med. Pharm. Sci. contributor: fullname: Dallagnol – volume: 3 year: 2023 ident: 10.1016/j.jtemin.2024.100199_bib0057 article-title: Quercetin and catechin supplementation provide protection against arsenic and mancozeb-induced toxicity in Wistar rats publication-title: Food Chem. Advances doi: 10.1016/j.focha.2023.100380 contributor: fullname: Yousuf – volume: 11 start-page: 2964 year: 2023 ident: 10.1016/j.jtemin.2024.100199_bib0058 article-title: Neuroprotective effect of quercetin and Zingiber officinale on sodium arsenate-induced neurotoxicity in rats publication-title: Food Sci. Nutri. doi: 10.1002/fsn3.3278 contributor: fullname: Yousuf – volume: 21 start-page: 333 year: 1984 ident: 10.1016/j.jtemin.2024.100199_bib0026 article-title: Lead-induced regional lipid peroxidation in brain publication-title: Toxicol. Lett. doi: 10.1016/0378-4274(84)90093-6 contributor: fullname: Shafiq-Ur-Rehman – volume: 24 start-page: 1186 year: 2017 ident: 10.1016/j.jtemin.2024.100199_bib0060 article-title: Neuroprotective effects of quercetin in diabetic rat retina publication-title: Saudi J. Biol. Sci. doi: 10.1016/j.sjbs.2016.11.017 contributor: fullname: Ola – volume: 1 start-page: 650 year: 2007 ident: 10.1016/j.jtemin.2024.100199_bib0051 article-title: Ameliorative effect of ginger (Zingiber officinale) on mancozeb fungicide induced liver injury in Albino rats publication-title: Aust. J. Basic Appl. Sci. contributor: fullname: Sakr – volume: 38 start-page: 142 year: 2016 ident: 10.1016/j.jtemin.2024.100199_bib0015 article-title: Total antioxidant and oxidant status of plasma and renal tissue of cisplatin-induced nephrotoxic rats: Protection by floral extracts of Calendula officinalis Linn publication-title: Renal Failure doi: 10.3109/0886022X.2015.1103585 contributor: fullname: Verma – volume: 70 start-page: 245 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0050 article-title: Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in-vivo in Wistar rats publication-title: Cytotechnol doi: 10.1007/s10616-017-0138-8 contributor: fullname: Cheruku – volume: 38 start-page: 395 year: 2000 ident: 10.1016/j.jtemin.2024.100199_bib0031 article-title: Hepatic damage caused by chronic arsenic toxicity in experimental animals publication-title: Clin. Toxicol. contributor: fullname: Santra – volume: 6 start-page: 348 year: 2015 ident: 10.1016/j.jtemin.2024.100199_bib0001 article-title: A Review on Toxicological Effects of Fungicides publication-title: Res. J. Pharm. Biol. Chem. Sci. contributor: fullname: Preeti – volume: 120 start-page: 439 issue: 2 year: 2011 ident: 10.1016/j.jtemin.2024.100199_bib0006 article-title: Exposure to the widely used fungicide mancozeb causes thyroid harmone disruption in rat dams but no behavioral effects in the offspring publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfr006 contributor: fullname: Axelstad – volume: 212 start-page: 89 issue: 2 year: 2006 ident: 10.1016/j.jtemin.2024.100199_bib0005 article-title: Molecular mechanisms underlying mancozeb-induced inhibition of TNF-alpha production publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2005.07.002 contributor: fullname: Corsini – volume: 16 year: 2019 ident: 10.1016/j.jtemin.2024.100199_bib0013 article-title: Perspectives on arsenic toxicity, carcinogenicity and its systemic remediation strategies publication-title: Environ. Technol. Innov. doi: 10.1016/j.eti.2019.100462 contributor: fullname: Sodhi – volume: 5 year: 2023 ident: 10.1016/j.jtemin.2024.100199_bib0054 article-title: Ameliorative potential of quercetin and catechin against sodium arsenite and mancozeb-induced oxidative renal damage in Wistar rats publication-title: J. Trace Ele. Minerals contributor: fullname: Yousuf – volume: 6 start-page: 163 year: 2014 ident: 10.1016/j.jtemin.2024.100199_bib0043 article-title: Serum paraoxonase/arylesterase activity and oxidative stress status in children with metabolic syndrome publication-title: J. Clin. Res. Paed. Endocrinol. doi: 10.4274/jcrpe.1454 contributor: fullname: Eren – volume: 47 start-page: 469 year: 1974 ident: 10.1016/j.jtemin.2024.100199_bib0021 article-title: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1974.tb03714.x contributor: fullname: Marklund – volume: 35 start-page: 265 year: 2019 ident: 10.1016/j.jtemin.2024.100199_bib0029 article-title: Mancozeb fungicide-induced genotoxic effects, metabolic alterations, and histological changes in the colon and liver of Sprague Dawley rats publication-title: Toxicol. Ind. Health doi: 10.1177/0748233719834150 contributor: fullname: Yahia – volume: 60 start-page: 23 year: 2012 ident: 10.1016/j.jtemin.2024.100199_bib0042 article-title: Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism publication-title: J. Invest. Med. doi: 10.2310/JIM.0b013e31823581dd contributor: fullname: Cebeci – volume: 54 start-page: 354 year: 2016 ident: 10.1016/j.jtemin.2024.100199_bib0014 article-title: Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation by Pistacia lentiscus oil publication-title: Pharmaceut. Biol. doi: 10.3109/13880209.2015.1043562 contributor: fullname: Klibet – volume: 90 start-page: 815 year: 2012 ident: 10.1016/j.jtemin.2024.100199_bib0008 article-title: Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes publication-title: Life Sci. doi: 10.1016/j.lfs.2011.12.013 contributor: fullname: Srivastava – volume: 23 start-page: 269 year: 1994 ident: 10.1016/j.jtemin.2024.100199_bib0020 article-title: Measurement of antioxidants in human blood plasma publication-title: Methods Enzymol. doi: 10.1016/0076-6879(94)34094-3 contributor: fullname: Motchnik – volume: 94 start-page: 1077 year: 2010 ident: 10.1016/j.jtemin.2024.100199_bib0003 article-title: Mancozeb past, present and future publication-title: The American Phytopathological Society contributor: fullname: Gullino – volume: 3 year: 2019 ident: 10.1016/j.jtemin.2024.100199_bib0046 article-title: Quercetin abates induction of hepatic and renal oxidative damage, inflammation, and apoptosis in carbendazim-treated rats publication-title: Toxicol. Res. Appl. contributor: fullname: Owumi – ident: 10.1016/j.jtemin.2024.100199_bib0028 – volume: 25 start-page: 1270 year: 2018 ident: 10.1016/j.jtemin.2024.100199_bib0045 article-title: Assessment of protective potential of Nigella sativa oil against carbendazim-and/or mancozeb-induced hematotoxicity, hepatotoxicity, and genotoxicity publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-017-0542-9 contributor: fullname: Hashem – volume: 30 start-page: 255 year: 2023 ident: 10.1016/j.jtemin.2024.100199_bib0055 article-title: Testicular Toxicity following subacute exposure of arsenic and mancozeb alone and in combination: Ameliorative efficacy of quercetin and catechin publication-title: Toxicol. Int. doi: 10.18311/ti/2023/v30i3/32276 contributor: fullname: Yousuf – start-page: 91 year: 1997 ident: 10.1016/j.jtemin.2024.100199_bib0016 article-title: Thiodithiocarbamates contributor: fullname: Edward – start-page: 673 year: 1983 ident: 10.1016/j.jtemin.2024.100199_bib0022 article-title: Catalase contributor: fullname: Aebi |
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Snippet | Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As+3) in the groundwater is likely to cause toxicosis in humans and... Background: Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As+3) in the groundwater is likely to cause toxicosis in... |
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SubjectTerms | Arsenic Catechin Hepatotoxicity Mancozeb Oxidative damage Quercetin |
Title | Hepatotoxicity induced by subacute exposure of Mancozeb and Arsenic in Wistar rats: Mitigating effect of quercetin and catechin |
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